Habib Yaribeygi
Anti-inflammatory potentials of incretin-based therapies used in the management of diabetes
Yaribeygi, Habib; Maleki, Mina; Sathyapalan, Thozhukat; Jamialahmadi, Tannaz; Sahebkar, Amirhossein
Authors
Mina Maleki
Professor Thozhukat Sathyapalan T.Sathyapalan@hull.ac.uk
Professor of Diabetes, Endocrinology and Metabolism
Tannaz Jamialahmadi
Amirhossein Sahebkar
Abstract
GLP-1 receptor agonists (GLP-1RA) and dipeptidyl peptidase 4 inhibitors (DPP-4i) are two classes of antidiabetic agents used in the management of diabetes based on incretin hormones. There is emerging evidence that they have anti-inflammatory effects. Since most long-term complications of diabetes have a background of chronic inflammation, these agents may be beneficial against diabetic complications not only due to their hypoglycemic potential but also via their anti-inflammatory effects. However, the exact molecular mechanisms by which GLP-1RAs and DPP-4i exert their anti-inflammatory effects are not clearly understood. In this review, we discuss the potential molecular pathways by which these incretin-based therapies exert their anti-inflammatory effects.
Citation
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2020). Anti-inflammatory potentials of incretin-based therapies used in the management of diabetes. Life Sciences, 241, Article 117152. https://doi.org/10.1016/j.lfs.2019.117152
Journal Article Type | Review |
---|---|
Acceptance Date | Dec 8, 2019 |
Online Publication Date | Dec 13, 2019 |
Publication Date | Jan 15, 2020 |
Deposit Date | Dec 18, 2019 |
Publicly Available Date | Dec 14, 2020 |
Journal | Life Sciences |
Print ISSN | 0024-3205 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 241 |
Article Number | 117152 |
DOI | https://doi.org/10.1016/j.lfs.2019.117152 |
Keywords | General Pharmacology, Toxicology and Pharmaceutics; General Biochemistry, Genetics and Molecular Biology; General Medicine; GLP-1 receptor agonist; DPP-4 inhibitor; Diabetes mellitus; Diabetic complication; Inflammation |
Public URL | https://hull-repository.worktribe.com/output/3327318 |
Additional Information | This article is maintained by: Elsevier; Article Title: Anti-inflammatory potentials of incretin-based therapies used in the management of diabetes; Journal Title: Life Sciences; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.lfs.2019.117152; Content Type: article; Copyright: © 2019 Elsevier Inc. All rights reserved. |
Contract Date | Dec 18, 2019 |
Files
Article
(479 Kb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/
You might also like
Molecular Aspects of Cardiovascular Risk Factors
(2024)
Journal Article
Effect of Hypoglycemia and Rebound Hyperglycemia on Proteomic Cardiovascular Risk Biomarkers
(2024)
Journal Article
Downloadable Citations
About Repository@Hull
Administrator e-mail: repository@hull.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search