The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review

Yaribeygi, Habib; Maleki, Mina; Sathyapalan, Thozhukat; Iranpanah, Helia; Orafai, Hossein M.; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

Abstract

Diabetes mellitus (DM) is a complex metabolic disorder involving multiple deleterious molecular pathways and cellular defects leading to disturbance in the biologic milieu. It is currently a global health concern with growing incidence, especially among younger adults. There is an unmet need to find new therapeutic targets for the management of diabetes. Vitamin D is a promising target in the pathophysiology of DM, especially since vitamin D deficiency is common in patients with diabetes compared to people without diabetes. Evidence suggests that it can play significant roles in improving peripheral insulin sensitivity and glucose metabolism, however, the exact pathophysiological mechanism is not clarified yet. In this current study, we have reviewed the evidence on the effect of vitamin D in improving insulin resistance via distinct molecular pathways.

Citation

Yaribeygi, H., Maleki, M., Sathyapalan, T., Iranpanah, H., Orafai, H. M., Jamialahmadi, T., & Sahebkar, A. (2020). The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review. Life Sciences, 244, Article 117305. https://doi.org/10.1016/j.lfs.2020.117305

• Journal Article Type: Review
• Acceptance Date: Jan 16, 2020
• Online Publication Date: Jan 14, 2020
• Publication Date: Mar 1, 2020
• Deposit Date: Jan 19, 2020
• Publicly Available Date: Jan 15, 2021
• Journal: Life Sciences
• Print ISSN: 0024-3205
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 244
• Article Number: 117305
• DOI: https://doi.org/10.1016/j.lfs.2020.117305
• Keywords: Diabetes mellitus; Insulin resistance; Insulin signal transduction; Insulin sensitivity; Calcitriol; Vitamin D3; Colecalciferol
• Public URL: https://hull-repository.worktribe.com/output/3376256
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S0024320520300527?via%3Dihub
• Contract Date: Jan 19, 2020