The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review
Yaribeygi, Habib; Maleki, Mina; Sathyapalan, Thozhukat; Iranpanah, Helia; Orafai, Hossein M.; Jamialahmadi, Tannaz; Sahebkar, Amirhossein
Hossein M. Orafai
Diabetes mellitus (DM) is a complex metabolic disorder involving multiple deleterious molecular pathways and cellular defects leading to disturbance in the biologic milieu. It is currently a global health concern with growing incidence, especially among younger adults. There is an unmet need to find new therapeutic targets for the management of diabetes. Vitamin D is a promising target in the pathophysiology of DM, especially since vitamin D deficiency is common in patients with diabetes compared to people without diabetes. Evidence suggests that it can play significant roles in improving peripheral insulin sensitivity and glucose metabolism, however, the exact pathophysiological mechanism is not clarified yet. In this current study, we have reviewed the evidence on the effect of vitamin D in improving insulin resistance via distinct molecular pathways.
|Journal Article Type||Article|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Yaribeygi, H., Maleki, M., Sathyapalan, T., Iranpanah, H., Orafai, H. M., Jamialahmadi, T., & Sahebkar, A. (2020). The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review. Life Sciences, 117305. https://doi.org/10.1016/j.lfs.2020.117305|
|Keywords||GeneralPharmacology, Toxicology and Pharmaceutics; General Biochemistry, Genetics and Molecular Biology; General Medicine; Diabetes mellitus; Insulin resistanceInsulin signal transduction; Insulin sensitivity; Calcitriol; Vitamin D3; Colecalciferol|
This file is under embargo due to copyright reasons.
Contact T.Sathyapalan@hull.ac.uk to request a copy for personal use.
You might also like
Anti-inflammatory potentials of incretin-based therapies used in the management of diabetes