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The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review

Yaribeygi, Habib; Maleki, Mina; Sathyapalan, Thozhukat; Iranpanah, Helia; Orafai, Hossein M.; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

Authors

Habib Yaribeygi

Mina Maleki

Thozhukat Sathyapalan

Helia Iranpanah

Hossein M. Orafai

Tannaz Jamialahmadi

Amirhossein Sahebkar



Abstract

Diabetes mellitus (DM) is a complex metabolic disorder involving multiple deleterious molecular pathways and cellular defects leading to disturbance in the biologic milieu. It is currently a global health concern with growing incidence, especially among younger adults. There is an unmet need to find new therapeutic targets for the management of diabetes. Vitamin D is a promising target in the pathophysiology of DM, especially since vitamin D deficiency is common in patients with diabetes compared to people without diabetes. Evidence suggests that it can play significant roles in improving peripheral insulin sensitivity and glucose metabolism, however, the exact pathophysiological mechanism is not clarified yet. In this current study, we have reviewed the evidence on the effect of vitamin D in improving insulin resistance via distinct molecular pathways.

Journal Article Type Article
Publication Date 2020-01
Journal Life Sciences
Print ISSN 0024-3205
Publisher Elsevier
Peer Reviewed Peer Reviewed
Pages 117305
APA6 Citation Yaribeygi, H., Maleki, M., Sathyapalan, T., Iranpanah, H., Orafai, H. M., Jamialahmadi, T., & Sahebkar, A. (2020). The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review. Life Sciences, 117305. https://doi.org/10.1016/j.lfs.2020.117305
DOI https://doi.org/10.1016/j.lfs.2020.117305
Keywords GeneralPharmacology, Toxicology and Pharmaceutics; General Biochemistry, Genetics and Molecular Biology; General Medicine; Diabetes mellitus; Insulin resistanceInsulin signal transduction; Insulin sensitivity; Calcitriol; Vitamin D3; Colecalciferol