MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress

Ashrafizadeh, Milad; Ahmadi, Zahra; Samarghandian, Saeed; Mohammadinejad, Reza; Yaribeygi, Habib; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Abstract

MicroRNAs (miRs) are small non-coding pieces of RNA that are involved in a variety of physiologic processes such as apoptosis, cell proliferation, cell differentiation, cell cycle and cell survival. These multifunctional nucleotides are also capable of preventing oxidative damages by modulating antioxidant defense systems in a variety of milieu, such as in diabetes. Although the exact molecular mechanisms by which miRs modulate the antioxidant defense elements are unclear, some evidence suggests that they may exert these effects via nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. This intracellular mechanism is crucial in the maintenance of the physiologic redox balance by regulating the expression and activity of various cellular antioxidative defense elements and thereby plays a pivotal role in the development of oxidative stress. Any impairment in the Nrf2 signaling pathway may result in oxidative damage-dependent complications such as various diabetic complications, neurological disorders and cancer. In the current review, we discuss the modulatory effects of miRs on the Nrf2 signaling pathway, which can potentially be novel therapeutic targets.

Citation

Ashrafizadeh, M., Ahmadi, Z., Samarghandian, S., Mohammadinejad, R., Yaribeygi, H., Sathyapalan, T., & Sahebkar, A. (2020). MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress. Life Sciences, 244, 117329. https://doi.org/10.1016/j.lfs.2020.117329

• Journal Article Type: Review
• Acceptance Date: Jan 15, 2020
• Online Publication Date: Jan 16, 2020
• Publication Date: Mar 1, 2020
• Deposit Date: Jan 20, 2020
• Publicly Available Date: Jan 17, 2021
• Journal: Life Sciences
• Print ISSN: 0024-3205
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 244
• Pages: 117329
• DOI: https://doi.org/10.1016/j.lfs.2020.117329
• Keywords: MicroRNAs; Oxidative stress; Nrf2 signaling pathway; Diabetes mellitus; Free radicals
• Public URL: https://hull-repository.worktribe.com/output/3377410
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S002432052030076X?via%3Dihub
• Contract Date: Jan 21, 2020