Incretins and microRNAs: Interactions and physiological relevance

Radbakhsh, Shabnam; Sathyapalan, Thozhukat; Banach, Maciej; Sahebkar, Amirhossein

Abstract

MicroRNAs (miRNA) are one class of the small regulatory RNAs that can impact the expression of numerous genes including incretin hormones and their G protein-coupled receptors. Incretin peptides, including GLP-1, GLP-2, and GIP, are released from the gastrointestinal tract and have an crucial role in the glucose hemostasis and pancreatic beta-cell function. These hormones and their analogs with a longer half-life, glucagon like peptide-1 receptor agonists (GLP1RA), modify the expression of miRNAs. Dipeptidyl peptidase IV (DPP-4) is an enzyme that degrades the incretin hormones and is inactivated by DPP-4 inhibitors, which are a class of compounds used in the management of type 2 diabetes. DPP-4 inhibitors may also increase or reduce the expression of miRNAs. In this review, we describe the possible interactions between miRNAs and incretin hormones and the relevance of such interactions to physiological processes and diseases.

Citation

Radbakhsh, S., Sathyapalan, T., Banach, M., & Sahebkar, A. (2020). Incretins and microRNAs: Interactions and physiological relevance. Pharmacological research : the official journal of the Italian Pharmacological Society, 153, Article 104662. https://doi.org/10.1016/j.phrs.2020.104662

• Journal Article Type: Review
• Acceptance Date: Jan 22, 2020
• Online Publication Date: Jan 23, 2020
• Publication Date: Mar 1, 2020
• Deposit Date: Jan 27, 2020
• Publicly Available Date: Jan 24, 2021
• Journal: Pharmacological Research
• Print ISSN: 1043-6618
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 153
• Article Number: 104662
• DOI: https://doi.org/10.1016/j.phrs.2020.104662
• Keywords: miRNAs; incretin; GLP1-Rincretin receptor agonist; DPP-4 inhibitor
• Public URL: https://hull-repository.worktribe.com/output/3394093
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S1043661819327392?via%3Dihub