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Incretins and microRNAs: interactions and physiological relevance

Radbakhsh, Shabnam; Sathyapalan, Thozhukat; Banach, Maciej; Sahebkar, Amirhossein

Authors

Shabnam Radbakhsh

Thozhukat Sathyapalan

Maciej Banach

Amirhossein Sahebkar



Abstract

MicroRNAs (miRNA) are one class of the small regulatory RNAs that can impact the expression of numerous genes including incretin hormones and their G protein-coupled receptors. Incretin peptides, including GLP-1, GLP-2, and GIP, are released from the gastrointestinal tract and have an crucial role in the glucose hemostasis and pancreatic beta-cell function. These hormones and their analogs with a longer half-life, glucagon like peptide-1 receptor agonists (GLP1RA), modify the expression of miRNAs. Dipeptidyl peptidase IV (DPP-4) is an enzyme that degrades the incretin hormones and is inactivated by DPP-4 inhibitors, which are a class of compounds used in the management of type 2 diabetes. DPP-4 inhibitors may also increase or reduce the expression of miRNAs. In this review, we describe the possible interactions between miRNAs and incretin hormones and the relevance of such interactions to physiological processes and diseases.

Journal Article Type Article
Journal Pharmacological Research
Print ISSN 1043-6618
Publisher Elsevier
Peer Reviewed Peer Reviewed
Article Number 104662
APA6 Citation Radbakhsh, S., Sathyapalan, T., Banach, M., & Sahebkar, A. (in press). Incretins and microRNAs: interactions and physiological relevance. Pharmacological research : the official journal of the Italian Pharmacological Society, https://doi.org/10.1016/j.phrs.2020.104662
DOI https://doi.org/10.1016/j.phrs.2020.104662
Keywords miRNAs; incretin; GLP1-Rincretin receptor agonist; DPP-4 inhibitor
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