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The role of interleukin-18 in the development and progression of atherosclerosis

Bahrami, Afsane; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Authors

Afsane Bahrami

Amirhossein Sahebkar



Abstract

Atherosclerosis (AS), as a chronic inflammatory disorder of the cardiovascular system, is one of the leading causes of ischemic heart disease, stroke and peripheral vascular disease. There is growing evidence on the role of innate and adaptive immunity in the pathogenesis of atherosclerosis. Interleukin-18 is one of the novel proinflammatory cytokines involved in atherogenesis, atherosclerotic plaque instability and plaque rupture. In this review, we overview the findings of preclinical and clinical studies about the role and mechanism of action of IL-18 in the pathogenesis of AS, which could offer novel prognostic and therapeutic approaches.

Citation

Bahrami, A., Sathyapalan, T., & Sahebkar, A. (2021). The role of interleukin-18 in the development and progression of atherosclerosis. Current medicinal chemistry, 28(9), 1757-1774. https://doi.org/10.2174/0929867327666200427095830

Journal Article Type Article
Acceptance Date Apr 6, 2020
Online Publication Date Apr 27, 2020
Publication Date Apr 20, 2021
Deposit Date May 2, 2020
Publicly Available Date Mar 29, 2024
Journal Current Medicinal Chemistry
Print ISSN 0929-8673
Electronic ISSN 1875-533X
Publisher Bentham Science Publishers
Peer Reviewed Peer Reviewed
Volume 28
Issue 9
Pages 1757-1774
DOI https://doi.org/10.2174/0929867327666200427095830
Keywords Matrix metalloproteases; Acute coronary syndromes; Vascular smooth muscle cells; Polymorphism
Public URL https://hull-repository.worktribe.com/output/3502571
Publisher URL http://www.eurekaselect.com/181368/article

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©2020 The authors. All rights reserved. No part of this publication may be reproduced without the written permission of the copyright holder





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