Curcumin for the management of periodontal diseases: a review

Forouzanfar, Fatemeh; Forouzanfar, Ali; Sathyapalan, Thozhukat; Orafai, Hossein M.; Sahebkar, Amirhossein

Abstract

Periodontal disease is one of the most common causes of tooth loss among adults. Research shows that inflammation is one of the crucial components in the initiation and progression of periodontitis. Various herbal medicines have recently been receiving attention for the management of periodontitis owing to their general safety and efficacy. Curcumin, a bioactive polyphenol extracted from Curcuma longa, has been shown to possess antioxidant, antimicrobial, anti-inflammatory and analgesic properties. Several studies have assessed the efficacy of curcumin against periodontal diseases. These studies have shown equivalent or even higher efficacy of curcumin compared to the commonly used medications for the management of periodontitis such as chlorhexidine. Herein, we review the experimental and clinical findings on the anti-periodontitis effects of curcumin and the pharmacological mechanisms underlying these effects.

Citation

Forouzanfar, F., Forouzanfar, A., Sathyapalan, T., Orafai, H. M., & Sahebkar, A. (2020). Curcumin for the management of periodontal diseases: a review. Current Pharmaceutical Design, 26(34), 4277-4284. https://doi.org/10.2174/1381612826666200513112607

• Journal Article Type: Review
• Acceptance Date: Sep 23, 2020
• Online Publication Date: Oct 12, 2020
• Publication Date: Oct 12, 2020
• Deposit Date: May 15, 2021
• Publicly Available Date: Oct 13, 2021
• Journal: Current Pharmaceutical Design
• Print ISSN: 1381-6128
• Publisher: Bentham Science Publishers
• Peer Reviewed: Peer Reviewed
• Volume: 26
• Issue: 34
• Pages: 4277-4284
• DOI: https://doi.org/10.2174/1381612826666200513112607
• Keywords: Inflammation; Gingivitis; Herbal medicine; Curcumin; Periodontitis; Herbal mouthwash
• Public URL: https://hull-repository.worktribe.com/output/3509317