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The role of whole genome sequencing in characterizing the mechanism of action of para-aminosalicylic acid and its resistance

Satta, Giovanni; Witney, Adam A.; Begum, Neelu; Ortiz Canseco, Julio; Boa, Andrew N.; McHugh, Timothy D.

Authors

Giovanni Satta

Adam A. Witney

Neelu Begum

Julio Ortiz Canseco

Timothy D. McHugh



Contributors

Abstract

Para-aminosalicylic acid (PAS) remains one of the drugs of last resort for the treatment of tuberculosis, but its mechanism of action is not completely understood yet. The main aim of this project was to identify new potential mechanisms of action and resistance to PAS by performing whole genome sequencing (WGS) on PAS-resistant laboratory mutants. A new variant in the folC gene has been identified as well as some other mutations that require further studies.

Citation

Satta, G., Witney, A. A., Begum, N., Ortiz Canseco, J., Boa, A. N., & McHugh, T. D. (2020). The role of whole genome sequencing in characterizing the mechanism of action of para-aminosalicylic acid and its resistance. Antimicrobial agents and chemotherapy, 64(9), Article e00675-20. https://doi.org/10.1128/AAC.00675-20

Journal Article Type Article
Acceptance Date Jun 13, 2020
Online Publication Date Jun 22, 2020
Publication Date Aug 20, 2020
Deposit Date Jul 6, 2020
Publicly Available Date Dec 23, 2020
Journal Antimicrobial agents and chemotherapy
Print ISSN 0066-4804
Publisher American Society for Microbiology
Peer Reviewed Peer Reviewed
Volume 64
Issue 9
Article Number e00675-20.
DOI https://doi.org/10.1128/AAC.00675-20
Keywords Pharmacology (medical); Pharmacology; Infectious Diseases
Public URL https://hull-repository.worktribe.com/output/3536793
Publisher URL https://aac.asm.org/content/early/2020/06/16/AAC.00675-20

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Published article (306 Kb)
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Copyright © 2020 American Society for Microbiology. All Rights Reserved.


Accepted article (444 Kb)
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Copyright Statement
©2020 The authors. All rights reserved. No part of this publication may be reproduced without the written permission of the copyright holder







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