The emerging role of the eosinophil and its measurement in chronic cough

Sadeghi, Mahboobeh H.; Morice, Alyn H.

Abstract

© 2017 Sadeghi & Morice. Although the aetiology of chronic cough in guidelines is clearly stated as asthma and related syndromes, gastrooesophageal reflux disease (GORD), and upper airways disease, the inflammatory mechanisms underlying these conditions differ. Recent studies on asthma have increasingly focused on its molecular phenotypes instead of clinical characteristics. Here, we proposed the hypothesis that divides cough into two groups; the eosinophilic and neutrophilic. This division will enhance our ability to recognise the type of airway inflammation which, as a consequence will lead us to more targeted and personalized treatment approaches.

Citation

Sadeghi, M. H., & Morice, A. H. (2017). The emerging role of the eosinophil and its measurement in chronic cough. Open Respiratory Medicine Journal, 11, 17-30. https://doi.org/10.2174/1874306401711010017

• Journal Article Type: Review
• Acceptance Date: May 8, 2017
• Online Publication Date: Jun 30, 2017
• Publication Date: 2017
• Deposit Date: May 10, 2022
• Publicly Available Date: May 23, 2022
• Journal: Open Respiratory Medicine Journal
• Electronic ISSN: 1874-3064
• Publisher: Bentham Open
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Pages: 17-30
• DOI: https://doi.org/10.2174/1874306401711010017
• Keywords: Chronic Cough; Eosinophil; Cough variant asthma; Eosinophilic bronchitis; Montelukast; Innate immunity
• Public URL: https://hull-repository.worktribe.com/output/3609828