The effect of deep hypothermia on the human pulmonary circulation

Ariyaratnam, Priyadharshanan; Loubani, Mahmoud; Cale, Alexander R.J.; Chaudhry, Mubarak; Cowen, Michael E.; Jarvis, Martin A.; Griffin, Steven; Morice, Alyn H.

Abstract

Objective: Acute rises in pulmonary artery pressures following complex cardiac surgery are associated with high morbidity and mortality. We hypothesised that periods of deep hypothermia predispose to elevated pulmonary pressures upon rewarming. We investigated the effect of this hypothermic preconditioning on isolated human pulmonary arteries and isolated perfused lungs. Methods: Isometric tension was measured in human pulmonary artery rings (n=24). We assessed the constriction and dilation of these arteries at 37. °C and 17. °C. Isolated perfused human lung models consisted of lobes ventilated via a bronchial cannula and perfused with Krebs via a pulmonary artery cannula. Bronchial and pulmonary artery pressures were recorded. We investigated the effect of temperature using a heat exchanger. Results: Rewarming from 17. °C to 37. °C caused a 1.3 fold increase in resting tension (p

Citation

Ariyaratnam, P., Loubani, M., Cale, A. R., Chaudhry, M., Cowen, M. E., Jarvis, M. A., Griffin, S., & Morice, A. H. (2014). The effect of deep hypothermia on the human pulmonary circulation. Journal of Thermal Biology, 40(1), 20-24. https://doi.org/10.1016/j.jtherbio.2014.01.001

• Journal Article Type: Article
• Acceptance Date: Jan 6, 2014
• Online Publication Date: Jan 13, 2014
• Publication Date: 2014-02
• Deposit Date: May 16, 2022
• Journal: Journal of Thermal Biology
• Print ISSN: 0306-4565
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 40
• Issue: 1
• Pages: 20-24
• DOI: https://doi.org/10.1016/j.jtherbio.2014.01.001
• Keywords: Hypothermia; Pulmonary hypertension
• Public URL: https://hull-repository.worktribe.com/output/3610077