Review article: Reflux in cough and airway disease

Morice, A. H.

Abstract

Chronic cough was previously thought to be attributed to three main aetiologies; asthma, reflux and postnasal drip. There is little to differentiate these three different diagnoses in the patients with chronic cough in terms of histology, cytokine profile or clinical history. In fact, the uniform clinical history exhibited by patients with chronic cough points to a single aetiology - airway reflux. In support of this, a questionnaire has been developed which identifies key elements within the clinical history which is answered positively by the overwhelming majority of patients presenting to a cough clinic. A new technology, including airway pH and exhaled breath condensate pepsin levels provide supporting evidence for the hypothesis that chronic cough is really a single diagnosis which has been termed the cough hypersensitivity syndrome. The syndrome is not necessarily precipitated by acid reflux and therefore therapy is directed more at motility and inhibition of the hypersensitivity components of the syndrome. The application of these diagnostic methodologies to other airway diseases such as severe asthma and recurrent exacerbations of COPD has revealed that many of the features of the cough hypersensitivity syndrome are also present in these conditions. © 2011 Blackwell Publishing Ltd.

Citation

Morice, A. H. (2011). Review article: Reflux in cough and airway disease. Alimentary Pharmacology and Therapeutics, 33(SUPPL. 1), 48-52. https://doi.org/10.1111/j.1365-2036.2011.4581.x

• Journal Article Type: Review
• Online Publication Date: Mar 1, 2011
• Publication Date: Apr 1, 2011
• Deposit Date: May 23, 2022
• Journal: Alimentary Pharmacology and Therapeutics
• Print ISSN: 0269-2813
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 33
• Issue: SUPPL. 1
• Pages: 48-52
• DOI: https://doi.org/10.1111/j.1365-2036.2011.4581.x
• Public URL: https://hull-repository.worktribe.com/output/3610271