Weitao Xu
Amino acid recognition by a fluorescent chemosensor based on cucurbit[8]uril and acridine hydrochloride
Xu, Weitao; Feng, Huaming; Zhao, Weiwei; Huang, Chunhua; Redshaw, Carl; Tao, Zhu; Xiao, Xin
Authors
Huaming Feng
Weiwei Zhao
Chunhua Huang
Professor Carl Redshaw C.Redshaw@hull.ac.uk
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry
Zhu Tao
Xin Xiao
Abstract
A new fluorescent chemosensor comprised of cucurbit[8]uril (Q[8]) and acridine hydrochloride (AC) has been designed and utilized for the recognition of amino acids. The AC was encapsulated by the Q[8] cavity and formed a 1:2 host-guest inclusion complex both in solution (aqueous) and in the solid-state. Whilst free AC is known to be strongly fluorescent, this strong fluorescence was quenched in the inclusion complex Q[8]-AC. This non-fluorescent complex Q[8]-AC was capable of serving as a fluorescence “off-on” probe, and was able to recognize either L-Phe or L-Trp via the competitive interaction between L-Phe or L-Trp. Moreover, the pH responsive nature of the probe allowed for the detection of basic amino acids, namely L-Arg, L-His, or L-Lys). As a result, a fluorescence method for the detection of five amino acids using a single system has been developed.
Citation
Xu, W., Feng, H., Zhao, W., Huang, C., Redshaw, C., Tao, Z., & Xiao, X. (2020). Amino acid recognition by a fluorescent chemosensor based on cucurbit[8]uril and acridine hydrochloride. Analytica Chimica Acta, 1135, 142-149. https://doi.org/10.1016/j.aca.2020.09.028
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 13, 2020 |
Online Publication Date | Sep 25, 2020 |
Publication Date | Oct 23, 2020 |
Deposit Date | Sep 26, 2020 |
Publicly Available Date | Sep 26, 2021 |
Journal | Analytica Chimica Acta |
Print ISSN | 0003-2670 |
Electronic ISSN | 1873-4324 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 1135 |
Pages | 142-149 |
DOI | https://doi.org/10.1016/j.aca.2020.09.028 |
Keywords | Chemosensor; cucurbit[8]uril; Recognition; “Off-on” probe; pH-responsive |
Public URL | https://hull-repository.worktribe.com/output/3618233 |
Publisher URL | https://www.sciencedirect.com/science/article/abs/pii/S0003267020309491?via%3Dihub |
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Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/
Copyright Statement
©2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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