Amino acid recognition by a fluorescent chemosensor based on cucurbituril and acridine hydrochloride
Xu, Weitao; Feng, Huaming; Zhao, Weiwei; Huang, Chunhua; Redshaw, Carl; Tao, Zhu; Xiao, Xin
Professor Carl Redshaw C.Redshaw@hull.ac.uk
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry
Dr Xin Xiao X.Xiao@hull.ac.uk
Senior Research Fellow
A new fluorescent chemosensor comprised of cucurbituril (Q) and acridine hydrochloride (AC) has been designed and utilized for the recognition of amino acids. The AC was encapsulated by the Q cavity and formed a 1:2 host-guest inclusion complex both in solution (aqueous) and in the solid-state. Whilst free AC is known to be strongly fluorescent, this strong fluorescence was quenched in the inclusion complex Q-AC. This non-fluorescent complex Q-AC was capable of serving as a fluorescence “off-on” probe, and was able to recognize either L-Phe or L-Trp via the competitive interaction between L-Phe or L-Trp. Moreover, the pH responsive nature of the probe allowed for the detection of basic amino acids, namely L-Arg, L-His, or L-Lys). As a result, a fluorescence method for the detection of five amino acids using a single system has been developed.
Xu, W., Feng, H., Zhao, W., Huang, C., Redshaw, C., Tao, Z., & Xiao, X. (2020). Amino acid recognition by a fluorescent chemosensor based on cucurbituril and acridine hydrochloride. Analytica Chimica Acta, 1135, 142-149. https://doi.org/10.1016/j.aca.2020.09.028
|Journal Article Type||Article|
|Acceptance Date||Sep 13, 2020|
|Online Publication Date||Sep 25, 2020|
|Publication Date||Oct 23, 2020|
|Deposit Date||Sep 26, 2020|
|Publicly Available Date||Sep 26, 2021|
|Journal||Analytica Chimica Acta|
|Peer Reviewed||Peer Reviewed|
|Keywords||Chemosensor; cucurbituril; Recognition; “Off-on” probe; pH-responsive|
This file is under embargo until Sep 26, 2021 due to copyright reasons.
Contact C.Redshaw@hull.ac.uk to request a copy for personal use.
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