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A fluorescent probe based on cucurbit[7]uril for the selective recognition of phenylalanine

Shan, Pei Hui; Kan, Jing Lan; Deng, Xin Yu; Redshaw, Carl; Bian, Bing; Fan, Ying; Tao, Zhu; Xiao, Xin


Pei Hui Shan

Jing Lan Kan

Xin Yu Deng

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Professor Carl Redshaw
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry

Bing Bian

Ying Fan

Zhu Tao

Xin Xiao


© 2020 Elsevier B.V. Herein we describe a simple fluorescence quenching method for the selective recognition and determination of the amino acid phenylalanine (Phe). The use of 1H NMR spectroscopy revealed that the alkaloid palmatine (PAL) can encapsulated partially into the cavity of cucurbit[7]uril (Q[7]) in aqueous solution to form a stable 1:1 host−guest inclusion complex. This host-guest complex exhibits fluorescence of moderate intensity. Interestingly, the addition of the Phe results in a dramatic quenching of the fluorescence intensity associated with the inclusion complex. By contrast, the addition of other natural amino acids resulted in no change in the fluorescence. Based on the linear relationship between the fluorescence intensity and the concentration of Phe, the detection of the concentration of Phe in aqueous solution is facile. Thus, a new fluorescence quenching method for the recognition and determination of the Phe has established herein.


Shan, P. H., Kan, J. L., Deng, X. Y., Redshaw, C., Bian, B., Fan, Y., …Xiao, X. (2020). A fluorescent probe based on cucurbit[7]uril for the selective recognition of phenylalanine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 233, Article 118177.

Journal Article Type Article
Acceptance Date Feb 17, 2020
Online Publication Date Feb 19, 2020
Publication Date Jun 5, 2020
Deposit Date Dec 8, 2020
Publicly Available Date Feb 20, 2021
Journal Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Print ISSN 1386-1425
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 233
Article Number 118177
Keywords Cucurbit[7]uril; Supramolecular assembly; Selective recognition; Fluorescent probe host−guest chemistry
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