A fluorescent probe based on cucurbit[7]uril for the selective recognition of phenylalanine

Shan, Pei Hui; Kan, Jing Lan; Deng, Xin Yu; Redshaw, Carl; Bian, Bing; Fan, Ying; Tao, Zhu; Xiao, Xin

Abstract

© 2020 Elsevier B.V. Herein we describe a simple fluorescence quenching method for the selective recognition and determination of the amino acid phenylalanine (Phe). The use of 1H NMR spectroscopy revealed that the alkaloid palmatine (PAL) can encapsulated partially into the cavity of cucurbit[7]uril (Q[7]) in aqueous solution to form a stable 1:1 host−guest inclusion complex. This host-guest complex exhibits fluorescence of moderate intensity. Interestingly, the addition of the Phe results in a dramatic quenching of the fluorescence intensity associated with the inclusion complex. By contrast, the addition of other natural amino acids resulted in no change in the fluorescence. Based on the linear relationship between the fluorescence intensity and the concentration of Phe, the detection of the concentration of Phe in aqueous solution is facile. Thus, a new fluorescence quenching method for the recognition and determination of the Phe has established herein.

Citation

Shan, P. H., Kan, J. L., Deng, X. Y., Redshaw, C., Bian, B., Fan, Y., Tao, Z., & Xiao, X. (2020). A fluorescent probe based on cucurbit[7]uril for the selective recognition of phenylalanine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 233, Article 118177. https://doi.org/10.1016/j.saa.2020.118177

• Journal Article Type: Article
• Acceptance Date: Feb 17, 2020
• Online Publication Date: Feb 19, 2020
• Publication Date: Jun 5, 2020
• Deposit Date: Dec 8, 2020
• Publicly Available Date: Feb 20, 2021
• Journal: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
• Print ISSN: 1386-1425
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 233
• Article Number: 118177
• DOI: https://doi.org/10.1016/j.saa.2020.118177
• Keywords: Cucurbit[7]uril; Supramolecular assembly; Selective recognition; Fluorescent probe host−guest chemistry
• Public URL: https://hull-repository.worktribe.com/output/3621709
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S1386142520301554?via%3Dihub#!