Rhenium(i) phenanthrolines bearing electron withdrawing CF3 substituents: Synthesis, characterization and biological evaluation

Redshaw, Carl; Watkins, Scott; Humphrey, Simon M.; Bulman Page, Philip C.; Ashby, Shane; Chao, Yimin; Herbert, Christopher J.; Mueller, Anja

Abstract

Rhenium(i) tricarbonyl complexes bearing a 2,4,7,9- tetraphenylphenanthroline ligand, where the 2,9-phenyl groups have either meta- or para-CF3 groups, have been screened against a selection of cell lines. The meta derivative shows anticancer activity against HeLa and A549 cell lines, whereas the para derivative causes proliferation of HL-60 cells, whilst showing toxicity towards A549 cells. © 2013 The Royal Society of Chemistry.

Citation

Redshaw, C., Watkins, S., Humphrey, S. M., Bulman Page, P. C., Ashby, S., Chao, Y., Herbert, C. J., & Mueller, A. (2013). Rhenium(i) phenanthrolines bearing electron withdrawing CF3 substituents: Synthesis, characterization and biological evaluation. RSC advances, 3(46), 23963-23966. https://doi.org/10.1039/c3ra43207f

• Journal Article Type: Article
• Acceptance Date: Oct 2, 2013
• Online Publication Date: Oct 4, 2013
• Publication Date: Dec 14, 2013
• Deposit Date: Jun 8, 2022
• Publicly Available Date: Dec 12, 2022
• Journal: RSC Advances
• Print ISSN: 2046-2069
• Electronic ISSN: 2046-2069
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 3
• Issue: 46
• Pages: 23963-23966
• DOI: https://doi.org/10.1039/c3ra43207f
• Public URL: https://hull-repository.worktribe.com/output/3621916