Incretin-based therapies and renin-angiotensin system: Looking for new therapeutic potentials in the diabetic milieu

Yaribeygi, Habib; Maleki, Mina; Sathyapalan, Thozhukat; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

Abstract

Incretin-based therapies include pharmacologic agents such as glucagon like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors which exert potent anti-hyperglycemic effects in the diabetic milieu. They are also shown to have extra-pancreatic effects. Renin-angiotensin system is part of the endocrine system which is widely distributed in the body and is closely involved in water and electrolyte homeostasis as well as renal and cardiovascular functions. Hence the renin-angiotensin system is the main target for treating patients with various renal and cardiovascular disorders. There is growing evidence that incretins have modulatory effects on renin-angiotensin system activity; thereby, can be promising therapeutic agents for the management of renal and cardiovascular disorders. But the exact molecular interactions between incretins and renin-angiotensin system are not clearly understood. In this current study, we have reviewed the possible molecular mechanisms by which incretins modulate renin-angiotensin system activity.

Citation

Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2020). Incretin-based therapies and renin-angiotensin system: Looking for new therapeutic potentials in the diabetic milieu. Life Sciences, 256, Article 117916. https://doi.org/10.1016/j.lfs.2020.117916

• Journal Article Type: Review
• Acceptance Date: Jun 4, 2020
• Online Publication Date: Jun 10, 2020
• Publication Date: Sep 1, 2020
• Deposit Date: May 15, 2021
• Publicly Available Date: Jun 11, 2021
• Journal: Life Sciences
• Print ISSN: 0024-3205
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 256
• Article Number: 117916
• DOI: https://doi.org/10.1016/j.lfs.2020.117916
• Keywords: Incretin; Glucagon like peptide-1 receptor agonists; Dipeptidyl peptdase-4 inhibitors; Renin-angiotensin system; Na+/H+ exchanger isotope 3
• Public URL: https://hull-repository.worktribe.com/output/3624628