Do Maternal Dietary Antioxidants Modify the Relationship Between Binge Drinking and Small for Gestational Age? Findings from a Longitudinal Cohort Study

Coathup, Victoria; Northstone, Kate; Izadi, Hooshang; Wheeler, Simon; Smith, Lesley

Abstract

Background: Vitamin C, vitamin E, and carotenoids are potent dietary antioxidants that have been shown to attenuate ethanol-induced harm in animal models of fetal alcohol spectrum disorders. A diet low in antioxidant-rich foods may induce a state of oxidative stress in the context of maternal alcohol consumption during pregnancy, potentially causing growth restriction in the developing fetus. Methods: We conducted a secondary analysis of a longitudinal U.K. birth cohort. The sample comprised 9,699 women and their babies in Avon, U.K., with an estimated delivery date between April 1, 1991 and December 31, 1992. Alcohol consumption data were self-reported at 18 weeks’ gestation via a postal questionnaire. Women reported any binge drinking (≥4 U.K. units/occasion) during the past month. Dietary data were self-reported at 32 weeks’ gestation using a food frequency questionnaire. Estimated intakes of vitamins C and E and carotenoids were categorized into quartiles. Logistic regression models with interaction terms were used to investigate relationships between maternal binge drinking, dietary antioxidants, and fetal growth. Models were adjusted for maternal sociodemographic and lifestyle characteristics. Small for gestational age (SGA;

Citation

Coathup, V., Northstone, K., Izadi, H., Wheeler, S., & Smith, L. (2018). Do Maternal Dietary Antioxidants Modify the Relationship Between Binge Drinking and Small for Gestational Age? Findings from a Longitudinal Cohort Study. Alcoholism: Clinical and Experimental Research, 42(11), 2196-2204. https://doi.org/10.1111/acer.13864

• Journal Article Type: Article
• Acceptance Date: Aug 2, 2018
• Online Publication Date: Aug 9, 2018
• Publication Date: Nov 1, 2018
• Deposit Date: Nov 15, 2021
• Journal: Alcoholism: Clinical and Experimental Research
• Print ISSN: 0145-6008
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 42
• Issue: 11
• Pages: 2196-2204
• DOI: https://doi.org/10.1111/acer.13864
• Keywords: Alcohol; Pregnancy; Dietary antioxidants; Small for gestational age; Avon Longitudinal Study of Parents and Children
• Public URL: https://hull-repository.worktribe.com/output/3629142
• Related Public URLs: https://research-information.bris.ac.uk/en/publications/do-maternal-dietary-antioxidants-modify-the-relationship-between-