Alexandra E. Butler
Metabolic comparison of polycystic ovarian syndrome and control women in Middle Eastern and UK Caucasian populations
Butler, Alexandra E.; Abouseif, Ahmed; Dargham, Soha R.; Sathyapalan, Thozhukat; Atkin, Stephen L.
Authors
Ahmed Abouseif
Soha R. Dargham
Professor Thozhukat Sathyapalan T.Sathyapalan@hull.ac.uk
Professor of Diabetes, Endocrinology and Metabolism
Stephen L. Atkin
Abstract
© 2020, The Author(s). To determine if metabolic characteristics differed in women with and without polycystic ovary syndrome (PCOS) between a Caucasian and Middle East population. Comparative cross-sectional analysis. Demographic and metabolic data from Middle Eastern women from Qatar Biobank (97 with PCOS, 622 controls) were compared to a Caucasian PCOS biobank in Hull UK (108 with PCOS, 69 controls). In both populations, PCOS women showed a worse cardiovascular risk profile of increased systolic and diastolic blood pressure, increased C-reactive protein (CRP), reduced HDL, insulin resistance as well as increased androgens compared to their respective controls without PCOS. UK women without PCOS had higher systolic and diastolic blood pressures, and increased testosterone results (p < 0.01) compared to Middle Eastern women without PCOS who had higher inflammatory markers (WBC and CRP), HDL and insulin resistance (p < 0.001). UK PCOS women had a higher body mass index, systolic and diastolic blood pressures, triglycerides (p < 0.01), whilst Middle Eastern PCOS women showed increased testosterone, free androgen index, HDL and CRP (P < 0.01). There was no difference in insulin or insulin resistance between the two PCOS cohorts. This study highlights ethnic population differences because, whilst cardiovascular risk indices were increased for both PCOS cohorts, this may be for different reasons: BMI, waist and hip measurements, systolic and diastolic blood pressure, and triglycerides were higher in the UK cohort whilst testosterone, HDL and CRP were higher in the Middle East population. Insulin resistance did not differ between the two PCOS populations despite differences in BMI.
Citation
Butler, A. E., Abouseif, A., Dargham, S. R., Sathyapalan, T., & Atkin, S. L. (2020). Metabolic comparison of polycystic ovarian syndrome and control women in Middle Eastern and UK Caucasian populations. Scientific reports, 10(1), Article 18895. https://doi.org/10.1038/s41598-020-75109-2
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 7, 2020 |
Online Publication Date | Nov 3, 2020 |
Publication Date | 2020-12 |
Deposit Date | Nov 4, 2020 |
Publicly Available Date | Nov 4, 2020 |
Journal | Scientific Reports |
Print ISSN | 2045-2322 |
Electronic ISSN | 2045-2322 |
Publisher | Nature Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 10 |
Issue | 1 |
Article Number | 18895 |
DOI | https://doi.org/10.1038/s41598-020-75109-2 |
Keywords | Endocrine system and metabolic diseases; Endocrinology |
Public URL | https://hull-repository.worktribe.com/output/3652221 |
Publisher URL | https://www.nature.com/articles/s41598-020-75109-2 |
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Copyright Statement
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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