Amir R. Afshari
Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme
Afshari, Amir R.; Motamed-Sanaye, Ali; Sabri, Hamed; Soltani, Arash; Karkon-Shayan, Sepideh; Radvar, Sarvin; Javid, Hossein; Mollazadeh, Hamid; Sathyapalan, Thozhukat; Sahebkar, Amirhossein
Authors
Ali Motamed-Sanaye
Hamed Sabri
Arash Soltani
Sepideh Karkon-Shayan
Sarvin Radvar
Hossein Javid
Hamid Mollazadeh
Professor Thozhukat Sathyapalan T.Sathyapalan@hull.ac.uk
Professor of Diabetes, Endocrinology and Metabolism
Amirhossein Sahebkar
Abstract
The current standard of care in glioblastoma multiforme (GBM), as the most morbid brain tumor, is not adequate, despite substantial progress in cancer therapy. Among patients receiving current standard treatments, including surgery, irradiation, and chemotherapy, the overall survival (OS) period with GBM is less than one year. The high mortality frequency of GBM is due to its aggressive nature, including accelerated growth, deregulated apoptosis, and invasion into surrounding tissues. The understanding of the molecular pathogenesis of GBM is, therefore, crucial for identifying, designing, and repurposing potential agents in future therapeutic approaches. In recent decades, it has been apparent that several neurotransmitters, specifically substance P (SP), an undecapeptide in the family of neuropeptides tachykinins, are found in astrocytes. After binding to the neurokinin-1 receptor (NK-1R), the SP controls cancer cell growth, exerts antiapoptotic impacts, stimulates cell invasion/metastasis, and activates vascularization. Since SP/NK-1R signaling pathway is a growth driver in many cancers, this potential mechanism is proposed as an additional target for treating GBM. Following an evaluation of the function of both SP and its NK-1R inhibitors in neoplastic cells, we recommend a unique and promising approach for the treatment of patients with GBM.
Citation
Afshari, A. R., Motamed-Sanaye, A., Sabri, H., Soltani, A., Karkon-Shayan, S., Radvar, S., Javid, H., Mollazadeh, H., Sathyapalan, T., & Sahebkar, A. (2021). Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme. Current medicinal chemistry, 28(24), 4877-4892. https://doi.org/10.2174/0929867328666210113165805
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 2, 2021 |
Online Publication Date | Jan 13, 2021 |
Publication Date | Jul 1, 2021 |
Deposit Date | May 15, 2021 |
Publicly Available Date | Jan 14, 2022 |
Journal | Current Medicinal Chemistry |
Print ISSN | 0929-8673 |
Publisher | Bentham Science Publishers |
Peer Reviewed | Peer Reviewed |
Volume | 28 |
Issue | 24 |
Pages | 4877-4892 |
DOI | https://doi.org/10.2174/0929867328666210113165805 |
Keywords | Glioblastoma multiforme; Apoptosis; Substance P; neurokinin-1 receptor (NK-1R); GBM; NK1R antagonists |
Public URL | https://hull-repository.worktribe.com/output/3694966 |
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