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Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme

Afshari, Amir R.; Motamed-Sanaye, Ali; Sabri, Hamed; Soltani, Arash; Karkon-Shayan, Sepideh; Radvar, Sarvin; Javid, Hossein; Mollazadeh, Hamid; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Authors

Amir R. Afshari

Ali Motamed-Sanaye

Hamed Sabri

Arash Soltani

Sepideh Karkon-Shayan

Sarvin Radvar

Hossein Javid

Hamid Mollazadeh

Amirhossein Sahebkar



Abstract

The current standard of care in glioblastoma multiforme (GBM), as the most morbid brain tumor, is not adequate, despite substantial progress in cancer therapy. Among patients receiving current standard treatments, including surgery, irradiation, and chemotherapy, the overall survival (OS) period with GBM is less than one year. The high mortality frequency of GBM is due to its aggressive nature, including accelerated growth, deregulated apoptosis, and invasion into surrounding tissues. The understanding of the molecular pathogenesis of GBM is, therefore, crucial for identifying, designing, and repurposing potential agents in future therapeutic approaches. In recent decades, it has been apparent that several neurotransmitters, specifically substance P (SP), an undecapeptide in the family of neuropeptides tachykinins, are found in astrocytes. After binding to the neurokinin-1 receptor (NK-1R), the SP controls cancer cell growth, exerts antiapoptotic impacts, stimulates cell invasion/metastasis, and activates vascularization. Since SP/NK-1R signaling pathway is a growth driver in many cancers, this potential mechanism is proposed as an additional target for treating GBM. Following an evaluation of the function of both SP and its NK-1R inhibitors in neoplastic cells, we recommend a unique and promising approach for the treatment of patients with GBM.

Citation

Afshari, A. R., Motamed-Sanaye, A., Sabri, H., Soltani, A., Karkon-Shayan, S., Radvar, S., Javid, H., Mollazadeh, H., Sathyapalan, T., & Sahebkar, A. (2021). Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme. Current medicinal chemistry, 28(24), 4877-4892. https://doi.org/10.2174/0929867328666210113165805

Journal Article Type Article
Acceptance Date Jan 2, 2021
Online Publication Date Jan 13, 2021
Publication Date Jul 1, 2021
Deposit Date May 15, 2021
Publicly Available Date Jan 14, 2022
Journal Current Medicinal Chemistry
Print ISSN 0929-8673
Publisher Bentham Science Publishers
Peer Reviewed Peer Reviewed
Volume 28
Issue 24
Pages 4877-4892
DOI https://doi.org/10.2174/0929867328666210113165805
Keywords Glioblastoma multiforme; Apoptosis; Substance P; neurokinin-1 receptor (NK-1R); GBM; NK1R antagonists
Public URL https://hull-repository.worktribe.com/output/3694966
This output contributes to the following UN Sustainable Development Goals:

SDG 3 - Good Health and Well-Being

Ensure healthy lives and promote well-being for all at all ages

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