Jamshid Gholizadeh Navashenaq
The role of myeloid-derived suppressor cells in rheumatoid arthritis: An update
Navashenaq, Jamshid Gholizadeh; Shabgah, Arezoo Gowhari; Hedayati-Moghadam, Mahdiyeh; Ariaee, Nazila; Mohammadi, Hamed; Hemmatzadeh, Maryam; Azhdari, Sara; Jamialahmadi, Tannaz; Sathyapalan, Thozhukat; Sahebkar, Amirhossein
Authors
Arezoo Gowhari Shabgah
Mahdiyeh Hedayati-Moghadam
Nazila Ariaee
Hamed Mohammadi
Maryam Hemmatzadeh
Sara Azhdari
Tannaz Jamialahmadi
Professor Thozhukat Sathyapalan T.Sathyapalan@hull.ac.uk
Professor of Diabetes, Endocrinology and Metabolism
Amirhossein Sahebkar
Abstract
© 2021 Rheumatoid arthritis (RA) is an autoimmune disease that generally affects the joints. In the late stages of the disease, it can be associated with several complications. Although the exact etiology of RA is unknown, various studies have been performed to understand better the immunological mechanisms involved in the pathogenesis of RA. At the onset of the disease, various immune cells migrate to the joints and increase the recruitment of immune cells to the joints by several immunological mediators such as cytokines and chemokines. The function of specific immune cells in RA is well-established. The shift of immune responses to Th1 or Th17 is one of the most essential factors in the development of RA. Myeloid-derived suppressor cells (MDSCs), as a heterogeneous population of myeloid cells, play a regulatory role in the immune system that inhibits T cell activity through several mechanisms. Various studies have been performed on the function of these cells in RA, which in some cases have yielded conflicting results. Therefore, the purpose of this review article is to comprehensively understand the pro-inflammatory and anti-inflammatory functions of MDSCs in the pathogenesis of RA.
Citation
Navashenaq, J. G., Shabgah, A. G., Hedayati-Moghadam, M., Ariaee, N., Mohammadi, H., Hemmatzadeh, M., …Sahebkar, A. (2021). The role of myeloid-derived suppressor cells in rheumatoid arthritis: An update. Life Sciences, 269, https://doi.org/10.1016/j.lfs.2021.119083
Journal Article Type | Review |
---|---|
Acceptance Date | Mar 2, 2021 |
Publication Date | Mar 15, 2021 |
Deposit Date | May 15, 2021 |
Publicly Available Date | Mar 28, 2024 |
Journal | Life Sciences |
Print ISSN | 0024-3205 |
Electronic ISSN | 1879-0631 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 269 |
DOI | https://doi.org/10.1016/j.lfs.2021.119083 |
Public URL | https://hull-repository.worktribe.com/output/3706267 |
Files
Blinded Manuscript RA 1
(1.5 Mb)
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Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/
Copyright Statement
©2021 Elsevier.
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