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The role of myeloid-derived suppressor cells in rheumatoid arthritis: An update

Navashenaq, Jamshid Gholizadeh; Shabgah, Arezoo Gowhari; Hedayati-Moghadam, Mahdiyeh; Ariaee, Nazila; Mohammadi, Hamed; Hemmatzadeh, Maryam; Azhdari, Sara; Jamialahmadi, Tannaz; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Authors

Jamshid Gholizadeh Navashenaq

Arezoo Gowhari Shabgah

Mahdiyeh Hedayati-Moghadam

Nazila Ariaee

Hamed Mohammadi

Maryam Hemmatzadeh

Sara Azhdari

Tannaz Jamialahmadi

Amirhossein Sahebkar



Abstract

© 2021 Rheumatoid arthritis (RA) is an autoimmune disease that generally affects the joints. In the late stages of the disease, it can be associated with several complications. Although the exact etiology of RA is unknown, various studies have been performed to understand better the immunological mechanisms involved in the pathogenesis of RA. At the onset of the disease, various immune cells migrate to the joints and increase the recruitment of immune cells to the joints by several immunological mediators such as cytokines and chemokines. The function of specific immune cells in RA is well-established. The shift of immune responses to Th1 or Th17 is one of the most essential factors in the development of RA. Myeloid-derived suppressor cells (MDSCs), as a heterogeneous population of myeloid cells, play a regulatory role in the immune system that inhibits T cell activity through several mechanisms. Various studies have been performed on the function of these cells in RA, which in some cases have yielded conflicting results. Therefore, the purpose of this review article is to comprehensively understand the pro-inflammatory and anti-inflammatory functions of MDSCs in the pathogenesis of RA.

Citation

Navashenaq, J. G., Shabgah, A. G., Hedayati-Moghadam, M., Ariaee, N., Mohammadi, H., Hemmatzadeh, M., …Sahebkar, A. (2021). The role of myeloid-derived suppressor cells in rheumatoid arthritis: An update. Life Sciences, 269, https://doi.org/10.1016/j.lfs.2021.119083

Journal Article Type Review
Acceptance Date Mar 2, 2021
Publication Date Mar 15, 2021
Deposit Date May 15, 2021
Publicly Available Date Mar 28, 2024
Journal Life Sciences
Print ISSN 0024-3205
Electronic ISSN 1879-0631
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 269
DOI https://doi.org/10.1016/j.lfs.2021.119083
Public URL https://hull-repository.worktribe.com/output/3706267

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