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Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals

Hosseini, Seyede Atefe; Zahedipour, Fatemeh; Sathyapalan, Thozhukat; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

Authors

Seyede Atefe Hosseini

Fatemeh Zahedipour

Tannaz Jamialahmadi

Amirhossein Sahebkar



Abstract

Pulmonary fibrosis (PF) is the devastating consequence of various inflammatory diseases of the lung. PF leads to a reduction of lung function, respiratory failure, and death. Several molecular pathways are involved in PF, such as inflammatory cytokines including tumor necrosis factor α (TNFα), tumor necrosis factor β1 (TNFβ1), interleukin 6 (IL-6), and interleukin 4 (IL-4), reactive oxygen species, matrix metalloproteases, and transforming growth factor-beta (TGF-β). Targeting these processes involved in the progression of PF is essential for the treatment of this disease. Natural products, including plant extracts and active compound that directly target the processes involved in PF, could be suitable therapeutic options with less adverse effects. In the present study, we reviewed the protective effects and the therapeutic role of various bioactive compounds from plants in PF management.

Citation

Hosseini, S. A., Zahedipour, F., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (in press). Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals. BioFactors, https://doi.org/10.1002/biof.1713

Journal Article Type Review
Acceptance Date Jan 21, 2021
Online Publication Date Feb 5, 2021
Deposit Date May 15, 2021
Publicly Available Date Mar 29, 2024
Journal BioFactors
Print ISSN 0951-6433
Electronic ISSN 1872-8081
Publisher Wiley
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1002/biof.1713
Keywords Curcumin; Herbal medicine; Lung; Pulmonary fibrosis
Public URL https://hull-repository.worktribe.com/output/3726554

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