Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?

Moin, Abu Saleh Md; Sathyapalan, Thozhukat; Butler, Alexandra E.; Atkin, Stephen L.

doi:10.3389/fendo.2021.638621

Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?

Moin, Abu Saleh Md; Sathyapalan, Thozhukat; Butler, Alexandra E.; Atkin, Stephen L.

Authors

Abu Saleh Md Moin

Professor Thozhukat Sathyapalan T.Sathyapalan@hull.ac.uk
Professor of Diabetes, Endocrinology and Metabolism

Alexandra E. Butler

Stephen L. Atkin

Abstract

© Copyright © 2021 Moin, Sathyapalan, Butler and Atkin. Background: Women with polycystic ovary syndrome (PCOS) often have vitamin D deficiency, a known risk factor for severe COVID-19 disease. Alveolar macrophage-derived cytokines contribute to the inflammation underlying pulmonary disease in COVID-19. We sought to determine if basal macrophage activation, as a risk factor for COVID-19 infection, was present in PCOS and, if so, was further enhanced by vitamin D deficiency. Methods: A cross-sectional study in 99 PCOS and 68 control women who presented sequentially. Plasma levels of a macrophage-derived cytokine panel were determined by Slow Off-rate Modified Aptamer (SOMA)-scan plasma protein measurement. Vitamin D was measured by tandem mass spectroscopy. Results: Vitamin D was lower in PCOS women (p

Citation

Moin, A. S. M., Sathyapalan, T., Butler, A. E., & Atkin, S. L. (2021). Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?. Frontiers in endocrinology, 12, Article 638621. https://doi.org/10.3389/fendo.2021.638621

Journal Article Type	Article
Acceptance Date	Jan 25, 2021
Online Publication Date	Feb 25, 2021
Publication Date	Feb 25, 2021
Deposit Date	May 15, 2021
Publicly Available Date	May 18, 2021
Journal	Frontiers in Endocrinology
Print ISSN	1664-2392
Electronic ISSN	1664-2392
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	12
Article Number	638621
DOI	https://doi.org/10.3389/fendo.2021.638621
Keywords	COVID-19 risk factors; Polycystic ovary disease; Vitamin D; Macrophage; Cytokines
Public URL	https://hull-repository.worktribe.com/output/3742743

Files

Published article (966 Kb)
PDF

Copyright Statement
Copyright © 2021 Moin, Sathyapalan, Butler and Atkin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.