Armita Mahdavi Gorabi
Effect of curcumin on proinflammatory cytokines: A meta-analysis of randomized controlled trials
Gorabi, Armita Mahdavi; Razi, Bahman; Aslani, Saeed; Abbasifard, Mitra; Imani, Danyal; Sathyapalan, Thozhukat; Sahebkar, Amirhossein
It has been suggested that curcumin has the potential for lowering inflammation. In the current meta-analysis, we attempted to clarify the efficacy of curcumin/turmeric supplementation in reducing concentrations of interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-α in patients with an inflammatory background. The main databases were searched to identify eligible trials evaluating the effect of curcumin in reducing IL-1, IL-6, IL-8, and TNF-α in serum up to March 2021. The effect sizes for weighted mean difference (WMD) and 95% confidence intervals (CI) were calculated. Overall, 32 randomized controlled trials (RCTs) were included. There was a significant decrease in the serum levels of IL-1 (WMD = −2.33 pg/ml, 95% CI = −3.33 to −1.34, P < 0.001) and TNF-α (WMD = −1.61 pg/ml, 95% CI = −2.72, −0.51, P < 0.001) compared to the placebo group following treatment. Nonetheless, curcumin/turmeric supplementation was non-significantly associated with reduced levels of IL-6 (WMD = −0.33 pg/ml, 95% CI = −0.99–0.34, P = 0.33) and increased levels of IL-8 (WMD = 0.52 pg/ml, 95% CI = −1.13–2.17, P = 0.53). The dose-responses analysis indicated that curcumin/turmeric supplementation resulted in IL-1 and IL-8 alteration in a non-linear model. Subgroup analysis according to duration and dose of treatment and target population revealed diverse outcomes. Curcumin could have a beneficial effect in reducing the proinflammatory cytokines IL-1 and TNF-α, but not IL-6 and IL-8 levels.
Gorabi, A. M., Razi, B., Aslani, S., Abbasifard, M., Imani, D., Sathyapalan, T., & Sahebkar, A. (2021). Effect of curcumin on proinflammatory cytokines: A meta-analysis of randomized controlled trials. Cytokine, 143, https://doi.org/10.1016/j.cyto.2021.155541
|Journal Article Type||Article|
|Acceptance Date||Apr 9, 2021|
|Online Publication Date||Apr 29, 2021|
|Deposit Date||May 15, 2021|
|Publicly Available Date||Apr 30, 2022|
|Peer Reviewed||Peer Reviewed|
|Keywords||Curcumin; Inflammation; Randomized controlled trials; Interleukin; TNF|
This file is under embargo until Apr 30, 2022 due to copyright reasons.
Contact T.Sathyapalan@hull.ac.uk to request a copy for personal use.
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