The Effects of Nutraceuticals and Herbal Medicine on Candida albicans in Oral Candidiasis: A Comprehensive Review

Gharibpour, Fateme; Shirban, Farinaz; Bagherniya, Mohammad; Nosouhian, Mohsen; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Abstract

Candida albicans is part of the healthy flora in the oral cavity. It can also cause opportunistic infection, which can be deleterious. The most typical type of chronic oral candidiasis is denture stomatitis, and C. albicans is identified as the most crucial organism in this situation. Due to the development of the resistant form of candida, using conventional drugs can sometimes be ineffective. Herbs and naturally imitative bioactive compounds could become a new source for antimycotic therapy. Several review studies suggest that herbal medicine and natural bioactive compounds have antibacterial, antiviral and antifungal effects. Thus, it is hypothesized that these natural products might have beneficial effects on pathogenic oral fungal flora such as C. albicans. Although the effects of herbs have been investigated as antifungal agents in several studies, to the best of our knowledge, the effects of these natural products on C. albicans have not yet been reviewed. Thus, the aim of this study was to review the anti-candida activity (especially C. albicans in oral candidiasis) of herbal medicines and natural bioactive compounds. It is concluded that, in general, medicinal plants and nutraceuticals such as garlic, green tea, propolis, curcumin, licorice root, cinnamon, resveratrol, ginger, and berberine are useful in the treatment of C. albicans in oral candidiasis and could be considered as a safe, accessible, and inexpensive management option in an attempt to prevent and treat oral diseases. However, most of the evidence is based on the in vitro and animal studies, so more clinical trials are needed.

Citation

Gharibpour, F., Shirban, F., Bagherniya, M., Nosouhian, M., Sathyapalan, T., & Sahebkar, A. (2021). The Effects of Nutraceuticals and Herbal Medicine on Candida albicans in Oral Candidiasis: A Comprehensive Review. In G. E. Barreto, & A. Sahebkar (Eds.), Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health (225-248). Cham: Springer Verlag. https://doi.org/10.1007/978-3-030-64872-5_16

• Online Publication Date: Apr 17, 2021
• Publication Date: 2021
• Deposit Date: Oct 2, 2022
• Publicly Available Date: Apr 18, 2023
• Publisher: Springer Verlag
• Pages: 225-248
• Series Title: Advances in experimental medicine and biology
• Series Number: 1308
• Book Title: Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health
• ISBN: 9783030648718
• DOI: https://doi.org/10.1007/978-3-030-64872-5_16
• Keywords: Candida albicans; Oral candidiasis; Nutraceuticals; Herbal medicine
• Public URL: https://hull-repository.worktribe.com/output/3761850
• Contract Date: Jan 1, 2021