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Antioxidative Potentials of Incretin-Based Medications: A Review of Molecular Mechanisms

Yaribeygi, Habib; Maleki, Mina; Sathyapalan, Thozhukat; Jamialahmadi, Tannaz; Sahebkar, Amirhossein


Habib Yaribeygi

Mina Maleki

Thozhukat Sathyapalan

Tannaz Jamialahmadi

Amirhossein Sahebkar


Glucagon-like peptide 1 receptor agonists and dipeptidyl-peptidase 4 inhibitors are medications used for managing diabetes, mimicking the metabolic effects of incretin hormones. Recent evidence suggests that these medications have antioxidative potentials in the diabetic milieu. The pathophysiology of most diabetic complications involves oxidative stress. Therefore, if incretin-based antidiabetic medications can alleviate the free radicals involved in oxidative stress, they can potentially provide further therapeutic effects against diabetic complications. However, the molecular mechanisms by which these medications protect against oxidative stress are not fully understood. In the current review, we discuss the potential molecular mechanisms behind these pharmacologic agents' antioxidative properties.


Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2021). Antioxidative Potentials of Incretin-Based Medications: A Review of Molecular Mechanisms. Oxidative Medicine and Cellular Longevity, 2021,

Journal Article Type Review
Acceptance Date Apr 16, 2021
Online Publication Date Apr 28, 2021
Publication Date 2021
Deposit Date Jun 10, 2021
Publicly Available Date Jun 11, 2021
Journal Oxidative Medicine and Cellular Longevity
Print ISSN 1942-0900
Electronic ISSN 1942-0994
Publisher Hindawi
Peer Reviewed Peer Reviewed
Volume 2021
Article Number 9959320
Public URL


Published article (780 Kb)

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Copyright Statement
Copyright © 2021 Habib Yaribeygi et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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