Skip to main content

Research Repository

Advanced Search

Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis

Aalami, Amir Hossein; Abdeahad, Hossein; Mesgari, Mohammad; Sathyapalan, Thozhukat; Sahebkar, Amirhossein


Amir Hossein Aalami

Hossein Abdeahad

Mohammad Mesgari

Thozhukat Sathyapalan

Amirhossein Sahebkar


Aims. Bladder cancer (BCa) is a common cancer in North America and Europe that carries considerable morbidity and mortality. A reliable biomarker for early detection of the bladder is crucial for improving the prognosis of BCA. In this meta-analysis, we examine the diagnostic role of the angiogenin (ANG) protein in patients' urine with bladder neoplasm. Methods. We performed a systematic literature search using ScienceDirect, Web of Science, PubMed/MEDLINE, Scopus, Google Scholar, and Embase, up to 10th October 2020 databases. Meta-Disc V.1.4 and Comprehensive Meta-Analysis V.2.2 software calculated the pooled specificity, sensitivity, area under the curve (AUC), diagnostic odds ratio (DOR), positive likelihood ratio (LR+), negative likelihood ratio (LR-), Q∗ index, and summary receiver-operating characteristic (SROC) for the role of ANG as a urinary biomarker for BCa patients. Results. Four case-control studies were included with 656 participants (417 cases and 239 controls) in this meta-analysis. The pooled sensitivity of 0.71 (95% CI: 0.66-0.75), specificity of 0.78 (95% CI: 0.73-0.81), LR+ of 3.34 (95% CI: 2.02-5.53), LR- of 0.37 (95% CI: 0.32-0.44), DOR of 9.99 (95% CI: 4.69-21.28), and AUC of 0.789 and Q∗ index of 0.726 demonstrate acceptable diagnostic precision of ANG in identifying BCa. Conclusion. This meta-analysis showed that ANG could be a fair biomarker for the diagnosis of BCa patients.


Aalami, A. H., Abdeahad, H., Mesgari, M., Sathyapalan, T., & Sahebkar, A. (2021). Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis. Biomed research international, 2021,

Journal Article Type Review
Acceptance Date Apr 16, 2021
Online Publication Date Apr 28, 2021
Publication Date 2021
Deposit Date Jun 10, 2021
Publicly Available Date Jun 11, 2021
Journal BioMed Research International
Print ISSN 2314-6133
Electronic ISSN 2314-6141
Publisher Hindawi
Peer Reviewed Peer Reviewed
Volume 2021
Article Number 5557309
Public URL


Published article (908 Kb)

Publisher Licence URL

Copyright Statement
Copyright © 2021 Amir Hossein Aalami et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

You might also like

Downloadable Citations