Amir Hossein Aalami
Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis
Aalami, Amir Hossein; Abdeahad, Hossein; Mesgari, Mohammad; Sathyapalan, Thozhukat; Sahebkar, Amirhossein
Authors
Hossein Abdeahad
Mohammad Mesgari
Professor Thozhukat Sathyapalan T.Sathyapalan@hull.ac.uk
Professor of Diabetes, Endocrinology and Metabolism
Amirhossein Sahebkar
Abstract
Aims. Bladder cancer (BCa) is a common cancer in North America and Europe that carries considerable morbidity and mortality. A reliable biomarker for early detection of the bladder is crucial for improving the prognosis of BCA. In this meta-analysis, we examine the diagnostic role of the angiogenin (ANG) protein in patients' urine with bladder neoplasm. Methods. We performed a systematic literature search using ScienceDirect, Web of Science, PubMed/MEDLINE, Scopus, Google Scholar, and Embase, up to 10th October 2020 databases. Meta-Disc V.1.4 and Comprehensive Meta-Analysis V.2.2 software calculated the pooled specificity, sensitivity, area under the curve (AUC), diagnostic odds ratio (DOR), positive likelihood ratio (LR+), negative likelihood ratio (LR-), Q∗ index, and summary receiver-operating characteristic (SROC) for the role of ANG as a urinary biomarker for BCa patients. Results. Four case-control studies were included with 656 participants (417 cases and 239 controls) in this meta-analysis. The pooled sensitivity of 0.71 (95% CI: 0.66-0.75), specificity of 0.78 (95% CI: 0.73-0.81), LR+ of 3.34 (95% CI: 2.02-5.53), LR- of 0.37 (95% CI: 0.32-0.44), DOR of 9.99 (95% CI: 4.69-21.28), and AUC of 0.789 and Q∗ index of 0.726 demonstrate acceptable diagnostic precision of ANG in identifying BCa. Conclusion. This meta-analysis showed that ANG could be a fair biomarker for the diagnosis of BCa patients.
Citation
Aalami, A. H., Abdeahad, H., Mesgari, M., Sathyapalan, T., & Sahebkar, A. (2021). Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis. Biomed research international, 2021, Article 5557309. https://doi.org/10.1155/2021/5557309
Journal Article Type | Review |
---|---|
Acceptance Date | Apr 16, 2021 |
Online Publication Date | Apr 28, 2021 |
Publication Date | 2021 |
Deposit Date | Jun 10, 2021 |
Publicly Available Date | Jun 11, 2021 |
Journal | BioMed Research International |
Print ISSN | 2314-6133 |
Electronic ISSN | 2314-6141 |
Publisher | Hindawi |
Peer Reviewed | Peer Reviewed |
Volume | 2021 |
Article Number | 5557309 |
DOI | https://doi.org/10.1155/2021/5557309 |
Public URL | https://hull-repository.worktribe.com/output/3772727 |
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Copyright Statement
Copyright © 2021 Amir Hossein Aalami et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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