Obesity and Insulin Resistance: A Review of Molecular Interactions

Yaribeygi, Habib; Maleki, Mina; Sathyapalan, Thozhukat; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

Abstract

The prevalence of insulin resistance and diabetes mellitus is rising globally in epidemic proportions. Diabetes and its complications contribute to significant morbidity and mortality. An increase in sedentary lifestyle and consumption of a more energydense diet increased the incidence of obesity which is a significant risk factor for type 2 diabetes. Obesity acts as a potent upstream event that promotes molecular mechanisms involved in insulin resistance and diabetes mellitus. However, the exact molecular mechanisms between obesity and diabetes are not clearly understood. In the current study, we have reviewed the molecular interactions between obesity and type 2 diabetes.

Citation

Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2022). Obesity and Insulin Resistance: A Review of Molecular Interactions. Current Molecular Medicine, 21(3), 182-193. https://doi.org/10.2174/1566524020666200812221527

• Journal Article Type: Article
• Acceptance Date: Mar 17, 2022
• Online Publication Date: Aug 12, 2020
• Publication Date: Aug 24, 2022
• Deposit Date: Nov 6, 2022
• Publicly Available Date: Nov 10, 2022
• Journal: Current molecular medicine
• Print ISSN: 1566-5240
• Electronic ISSN: 1875-5666
• Publisher: Bentham Science Publishers
• Peer Reviewed: Peer Reviewed
• Volume: 21
• Issue: 3
• Pages: 182-193
• DOI: https://doi.org/10.2174/1566524020666200812221527
• Keywords: Diabetes mellitus; Obesity; Oxidative stress; Adipokine; Adiponectin; Adipocyte; Glut-4; Insulin signal transduction
• Public URL: https://hull-repository.worktribe.com/output/3772739