Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model

Ji, Bing; Yang, Qing; Genever, Paul G.; Fagan, Michael J.

Abstract

Multiple myeloma (MM)-induced bone disease is mortal for most MM patients. Bisphosphonates are first-line treatment for MM-induced bone disease, since it can inhibit osteoclast activity and the resultant bone resorption by suppressing the differentiation of osteoclast precursors into mature osteoclasts, promoting osteoclast apoptosis and disrupting osteoclast function. However, it is still unclear whether bisphosphonates have an anti-tumour effect. In our previous work, a computational model was built to simulate the pathology of MM-induced bone disease. This paper extends this proposed computational model to investigate the efficacy of bisphosphonates treatment and then clear the controversy of this therapy. The extended model is validated through the good agreement between simulation results and experimental data. The simulation results suggest that bisphosphonates indeed have an anti-tumour effect.

Citation

Ji, B., Yang, Q., Genever, P. G., & Fagan, M. J. Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model

• Presentation Conference Type: Conference Paper (published)
• Acceptance Date: Sep 28, 2014
• Publication Date: Dec 1, 2014
• Deposit Date: Oct 26, 2015
• Publicly Available Date: Nov 23, 2017
• Journal: Bio-medical materials and engineering
• Print ISSN: 0959-2989
• Publisher: IOS Press
• Peer Reviewed: Peer Reviewed
• Volume: 24
• Issue: 6
• Pages: 3373-3378
• DOI: https://doi.org/10.3233/BME-141160
• Keywords: Multiple myeloma, MM-induced bone disease,, Bisphosphonates, Anti-tumour, Computational model
• Public URL: https://hull-repository.worktribe.com/output/380230
• Publisher URL: http://content.iospress.com/articles/bio-medical-materials-and-engineering/bme1160
• Additional Information: Copy of article first published in: Bio-medical materials and engineering, 2014, v.24, issue 6.
• Contract Date: Nov 23, 2017