University of Hull logo

Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model

Ji, Bing; Yang, Qing; Genever, Paul G.; Fagan, Michael J.

Authors

Bing Ji

Qing Yang

Paul G. Genever

Abstract

Multiple myeloma (MM)-induced bone disease is mortal for most MM patients. Bisphosphonates are first-line treatment for MM-induced bone disease, since it can inhibit osteoclast activity and the resultant bone resorption by suppressing the differentiation of osteoclast precursors into mature osteoclasts, promoting osteoclast apoptosis and disrupting osteoclast function. However, it is still unclear whether bisphosphonates have an anti-tumour effect. In our previous work, a computational model was built to simulate the pathology of MM-induced bone disease. This paper extends this proposed computational model to investigate the efficacy of bisphosphonates treatment and then clear the controversy of this therapy. The extended model is validated through the good agreement between simulation results and experimental data. The simulation results suggest that bisphosphonates indeed have an anti-tumour effect.

Journal Article Type Conference Paper
Publication Date Dec 1, 2014
Journal Bio-medical materials and engineering
Print ISSN 0959-2989
Electronic ISSN 1878-3619
Publisher IOS Press
Peer Reviewed Peer Reviewed
Volume 24
Issue 6
Pages 3373-3378
Institution Citation Ji, B., Yang, Q., Genever, P. G., & Fagan, M. J. (2014). Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model. Bio-medical materials and engineering, 24(6), 3373-3378. https://doi.org/10.3233/BME-141160
DOI https://doi.org/10.3233/BME-141160
Keywords Multiple myeloma, MM-induced bone disease,, Bisphosphonates, Anti-tumour, Computational model
Publisher URL http://content.iospress.com/articles/bio-medical-materials-and-engineering/bme1160
Copyright Statement This article is published with Open Access and distributed under the terms of the Creative Commons Attribution and Non-Commercial License.
Additional Information Copy of article first published in: Bio-medical materials and engineering, 2014, v.24, issue 6.

Files

Article.pdf (468 Kb)
PDF

Copyright Statement
This article is published with Open Access and distributed under the terms of the Creative Commons Attribution and Non-Commercial License.



You might also like


Downloadable Citations