Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model
Ji, Bing; Yang, Qing; Genever, Paul G.; Fagan, Michael J.
Paul G. Genever
Michael J. Fagan
Multiple myeloma (MM)-induced bone disease is mortal for most MM patients. Bisphosphonates are first-line treatment for MM-induced bone disease, since it can inhibit osteoclast activity and the resultant bone resorption by suppressing the differentiation of osteoclast precursors into mature osteoclasts, promoting osteoclast apoptosis and disrupting osteoclast function. However, it is still unclear whether bisphosphonates have an anti-tumour effect. In our previous work, a computational model was built to simulate the pathology of MM-induced bone disease. This paper extends this proposed computational model to investigate the efficacy of bisphosphonates treatment and then clear the controversy of this therapy. The extended model is validated through the good agreement between simulation results and experimental data. The simulation results suggest that bisphosphonates indeed have an anti-tumour effect.
Ji, B., Yang, Q., Genever, P. G., & Fagan, M. J. (2014). Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model. Bio-medical materials and engineering, 24(6), 3373-3378. https://doi.org/10.3233/BME-141160
|Journal Article Type||Conference Paper|
|Acceptance Date||Sep 28, 2014|
|Publication Date||Dec 1, 2014|
|Deposit Date||Oct 26, 2015|
|Publicly Available Date||Nov 23, 2017|
|Journal||Bio-medical materials and engineering|
|Peer Reviewed||Peer Reviewed|
|Keywords||Multiple myeloma, MM-induced bone disease,, Bisphosphonates, Anti-tumour, Computational model|
|Additional Information||Copy of article first published in: Bio-medical materials and engineering, 2014, v.24, issue 6.|
Publisher Licence URL
This article is published with Open Access and distributed under the terms of the Creative Commons Attribution and Non-Commercial License.
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