The Effects of Glucagon-Like Peptide-1 Receptor Agonists and Dipeptydilpeptidase-4 Inhibitors on Blood Pressure and Cardiovascular Complications in Diabetes

Yaribeygi, Habib; Farrokhi, Farin Rashid; Abdalla, Mohammed Altigani; Sathyapalan, Thozhukat; Banach, Maciej; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

Abstract

Glucagon-like peptide-1 receptor (GLP-1R) agonists are a class of newly introduced antidiabetic medications that potentially lower blood glucose by several molecular pathways. DPP-4 inhibitors are the other type of novel antidiabetic medications which act by preventing GLP-1 inactivation and thereby increasing the activity levels of GLP-1, leading to more glucose-induced insulin release from islet β-cells and suppression of glucagon release. Most patients with diabetes have concurrent hypertension and cardiovascular disorder. If antihyperglycemic agents can attenuate the risk of hypertension and cardiovascular disease, they will amplify their overall beneficial effects. There is conflicting evidence on the cardiovascular benefits of GLP-1R induction in laboratory studies and clinical trials. In this study, we have reviewed the main molecular mechanisms by which GLP-1R induction may modulate the cardiovascular function and the results of cardiovascular outcome clinical trials.

Citation

Yaribeygi, H., Farrokhi, F. R., Abdalla, M. A., Sathyapalan, T., Banach, M., Jamialahmadi, T., & Sahebkar, A. (2021). The Effects of Glucagon-Like Peptide-1 Receptor Agonists and Dipeptydilpeptidase-4 Inhibitors on Blood Pressure and Cardiovascular Complications in Diabetes. Journal of Diabetes Research, 2021, Article 6518221. https://doi.org/10.1155/2021/6518221

• Journal Article Type: Review
• Acceptance Date: Jun 14, 2021
• Online Publication Date: Jun 30, 2021
• Publication Date: 2021
• Deposit Date: Nov 6, 2022
• Publicly Available Date: Nov 7, 2022
• Journal: Journal of Diabetes Research
• Print ISSN: 2314-6745
• Electronic ISSN: 2314-6753
• Publisher: Hindawi
• Peer Reviewed: Peer Reviewed
• Volume: 2021
• Article Number: 6518221
• DOI: https://doi.org/10.1155/2021/6518221
• Public URL: https://hull-repository.worktribe.com/output/3813722