Study on the Preparation Technology of Omeprazole Vesicles

Deng, Wenjing; Wang, Zhimei; Zhang, Yuehuan; Chen, Qing; Xiao, Xin; Redshaw, Carl

Abstract

Herein a study on the process of converting omeprazole into omeprazole vesicles by a film dispersion method is presented. Using encapsulation efficiency as an index, the formulation and technology of omeprazole vesicles are optimized by a single factor experiment and a central composite design-response surface method. The optimized formulation and technology are as follows: the ratio of Tween-80 to cholesterol is 3 : 1, the hydration time is 65 min, the hydration temperature is 30°C, and hydration solvent pH is 11. Under such conditions, the average particle diameter of the obtained the omeprazole vesicles is 70 nm, and the encapsulation efficiency is 92.40%, which is close to the theoretical value of 93.43%. Transmission electron microscope (TEM) characterization reveals that the omeprazole vesicles are of regular spherical shape, and IR and TG characterization demonstrate that omeprazole has been encapsulated by the vesicles. The release time of pure omeprazole drug in simulated human intestinal fluid (pH = 6.8) is about 70 min, and the release time of omeprazole vesicles is ca 75 min, with a release rate of 33.19%.

Citation

Deng, W., Wang, Z., Zhang, Y., Chen, Q., Xiao, X., & Redshaw, C. (2021). Study on the Preparation Technology of Omeprazole Vesicles. Russian Journal of General Chemistry, 91(11), 2311-2319. https://doi.org/10.1134/S1070363221110190

• Journal Article Type: Article
• Acceptance Date: Nov 11, 2021
• Online Publication Date: Dec 17, 2021
• Publication Date: 2021-11
• Deposit Date: Dec 17, 2021
• Publicly Available Date: Dec 1, 2022
• Journal: Russian Journal of General Chemistry
• Print ISSN: 1070-3632
• Electronic ISSN: 1608-3350
• Publisher: Springer
• Peer Reviewed: Peer Reviewed
• Volume: 91
• Issue: 11
• Pages: 2311-2319
• DOI: https://doi.org/10.1134/S1070363221110190
• Keywords: Omeprazole; Vesicles; Encapsulation efficiency; Central composite design-response surface method
• Public URL: https://hull-repository.worktribe.com/output/3900138