Study on the Preparation Technology of Omeprazole Vesicles
Deng, Wenjing; Wang, Zhimei; Zhang, Yuehuan; Chen, Qing; Xiao, Xin; Redshaw, Carl
Professor Carl Redshaw C.Redshaw@hull.ac.uk
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry
Herein a study on the process of converting omeprazole into omeprazole vesicles by a film dispersion method is presented. Using encapsulation efficiency as an index, the formulation and technology of omeprazole vesicles are optimized by a single factor experiment and a central composite design-response surface method. The optimized formulation and technology are as follows: the ratio of Tween-80 to cholesterol is 3 : 1, the hydration time is 65 min, the hydration temperature is 30°C, and hydration solvent pH is 11. Under such conditions, the average particle diameter of the obtained the omeprazole vesicles is 70 nm, and the encapsulation efficiency is 92.40%, which is close to the theoretical value of 93.43%. Transmission electron microscope (TEM) characterization reveals that the omeprazole vesicles are of regular spherical shape, and IR and TG characterization demonstrate that omeprazole has been encapsulated by the vesicles. The release time of pure omeprazole drug in simulated human intestinal fluid (pH = 6.8) is about 70 min, and the release time of omeprazole vesicles is ca 75 min, with a release rate of 33.19%.
Deng, W., Wang, Z., Zhang, Y., Chen, Q., Xiao, X., & Redshaw, C. (2021). Study on the Preparation Technology of Omeprazole Vesicles. Russian Journal of General Chemistry, 91(11), 2311-2319. https://doi.org/10.1134/S1070363221110190
|Journal Article Type||Article|
|Acceptance Date||Nov 11, 2021|
|Online Publication Date||Dec 17, 2021|
|Deposit Date||Dec 17, 2021|
|Publicly Available Date||Dec 1, 2022|
|Journal||Russian Journal of General Chemistry|
|Peer Reviewed||Peer Reviewed|
|Keywords||Omeprazole; Vesicles; Encapsulation efficiency; Central composite design-response surface method|
This file is under embargo until Dec 1, 2022 due to copyright reasons.
Contact C.Redshaw@hull.ac.uk to request a copy for personal use.
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