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Parallel kinetic resolution of racemic 1-phenylethanol using quasi-enantiomeric combinations of carboxylic acids mediated by N,N′-dicyclohexylcarbodiimide and 3,5-lutidine

Al Shaye, Najla; Boa, Andrew; Boa, Andrew N.; Coulbeck, Elliot; Eames, J.

Authors

Najla Al Shaye

Elliot Coulbeck

J. Eames J.Eames@hull.ac.uk



Abstract

The parallel kinetic resolution of racemic 1-phenylethanol using an equimolar combination of quasi-enantiomeric 2-arylpropionic and butanoic acids mediated by a N,N′-dicyclohexylcarbodiimide (DCC)/3,5-lutidine coupling is discussed. The levels of diastereoselectivity were high leading to separable quasi-enantiomeric esters in good yield. © 2008 Elsevier Ltd. All rights reserved.

Journal Article Type Article
Publication Date Jul 28, 2008
Journal Tetrahedron Letters
Print ISSN 0040-4039
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 49
Issue 31
Pages 4661-4665
APA6 Citation Shaye, N., Coulbeck, E., Boa, A., Al Shaye, N., Boa, A. N., Coulbeck, E., & Eames, J. (2008). Parallel kinetic resolution of racemic 1-phenylethanol using quasi-enantiomeric combinations of carboxylic acids mediated by N,N′-dicyclohexylcarbodiimide and 3,5-lutidine. Tetrahedron letters; the international organ for the rapid publication of preliminary communications in organic chemistry, 49(31), 4661-4665. https://doi.org/10.1016/j.tetlet.2008.05.036
DOI https://doi.org/10.1016/j.tetlet.2008.05.036
Publisher URL https://www.sciencedirect.com/science/article/pii/S0040403908009313?via%3Dihub
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