Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer

Pashirzad, Mehran; Sathyapalan, Thozhukat; Sheikh, Afsana; Kesharwani, Prashant; Sahebkar, Amirhossein

Abstract

Colorectal cancer (CRC) is one of the most common types of cancer globally. A subpopulation of tumour cells, cancer stem cells (CSC), is speculated to be responsible for tumor initiation, development, maintenance, metastasis, and recurrence. Colorectal cancer stem cells (CRC-SCs) have demonstrated some unique features, including a high level of heterogeneity and plasticity. This review summarizes the current understanding of CRC-SCs in the progression of CRC and the prognostic importance of these CSCs and their markers in colorectal cancer. Moreover, we have also discussed about various therapeutic approaches against markers-expressing CRC-SC.

Citation

Pashirzad, M., Sathyapalan, T., Sheikh, A., Kesharwani, P., & Sahebkar, A. (2022). Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer. Process Biochemistry, 115, 19-29. https://doi.org/10.1016/j.procbio.2022.02.006

• Journal Article Type: Review
• Acceptance Date: Feb 7, 2022
• Online Publication Date: Feb 10, 2022
• Publication Date: 2022-04
• Deposit Date: Nov 6, 2022
• Publicly Available Date: Feb 11, 2023
• Journal: Process Biochemistry
• Print ISSN: 1359-5113
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 115
• Pages: 19-29
• DOI: https://doi.org/10.1016/j.procbio.2022.02.006
• Keywords: Colorectal cancer; Cancer stem cells; Signal transduction; Therapeutic approaches; Chemoresistance
• Public URL: https://hull-repository.worktribe.com/output/3928359