A new cucurbit[10]uril-based AIE fluorescent supramolecular polymer for cellular imaging

Luo, Yang; Gan, Shiquan; Zhang, Wei; Jia, Menghao; Chen, Lixia; Redshaw, Carl; Tao, Zhu; Xiao, Xin

Abstract

To further advance the development of cucurbit[10]uril-based supramolecular biomaterials, an AIE fluorescent supramolecular polymer (TPE-B@Q[10]) was constructed from the newly synthesized AIE molecule TPE-B and Q[10] via host-guest interactions in a host/guest ratio of 2: 1. TPE-B@Q[10] not only has excellent blue fluorescence emission properties, but also possesses good biocompatibility and low toxicity. Therefore, TPE-B@Q[10] was successfully used for cytoplasmic imaging of cells. Flow cytometry further illustrated that Q[10] is capable of generating an alternative way to increase the fluorescence of TPE-B and its characteristic pattern for cellular imaging. This work provides a theoretical basis for promoting the application of cucurbit[n]uril-based supramolecular polymers in cell biology, and promotes the further development of cucurbit[n]uril chemistry.

Citation

Luo, Y., Gan, S., Zhang, W., Jia, M., Chen, L., Redshaw, C., Tao, Z., & Xiao, X. (2022). A new cucurbit[10]uril-based AIE fluorescent supramolecular polymer for cellular imaging. Materials Chemistry Frontiers, 6(8), 1021-1025. https://doi.org/10.1039/d2qm00084a

• Journal Article Type: Article
• Acceptance Date: Feb 22, 2022
• Online Publication Date: Feb 22, 2022
• Publication Date: Apr 21, 2022
• Deposit Date: Mar 13, 2022
• Publicly Available Date: Feb 23, 2023
• Journal: Materials Chemistry Frontiers
• Print ISSN: 2052-1537
• Electronic ISSN: 2052-1537
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Issue: 8
• Pages: 1021-1025
• DOI: https://doi.org/10.1039/d2qm00084a
• Keywords: Materials Chemistry; General Materials Science
• Public URL: https://hull-repository.worktribe.com/output/3938570