PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease

Shahbaz, Sanaz Keshavarz; Koushki, Khadijeh; Sathyapalan, Thozhukat; Majeed, Muhammed; Sahebkar, Amirhossein

doi:10.2174/1570159X19666210823103020

PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease

Shahbaz, Sanaz Keshavarz; Koushki, Khadijeh; Sathyapalan, Thozhukat; Majeed, Muhammed; Sahebkar, Amirhossein

Authors

Sanaz Keshavarz Shahbaz

Khadijeh Koushki

Professor Thozhukat Sathyapalan T.Sathyapalan@hull.ac.uk
Professor of Diabetes, Endocrinology and Metabolism

Muhammed Majeed

Amirhossein Sahebkar

Abstract

Progressive degeneration and dysfunction of the nervous system because of oxidative stress, aggregations of misfolded proteins, and neuroinflammation are the key pathological features of neurodegenerative diseases. Alzheimer's disease is a chronic neurodegenerative disorder driven by uncontrolled extracellular deposition of β-amyloid (Aβ) in the amyloid plaques and intracellular accumulation of hyperphosphorylated tau protein. Curcumin is a hydrophobic polyphenol with noticeable neuroprotective and anti-inflammatory effects that can cross the blood-brain barrier. Therefore, it is widely studied for the alleviation of inflammatory and neurological disorders. However, the clinical application of curcumin is limited due to its low aqueous solubility and bioavailability. Recently, nano-based curcumin delivery systems are developed to overcome these limitations effectively. This review article discusses the effects and potential mechanisms of curcumin-loaded PLGA nanoparticles in Alzheimer’s disease.

Citation

Shahbaz, S. K., Koushki, K., Sathyapalan, T., Majeed, M., & Sahebkar, A. (2022). PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease. Current Neuropharmacology, 20(2), 309-323. https://doi.org/10.2174/1570159X19666210823103020

Journal Article Type	Review
Acceptance Date	Jan 6, 2022
Online Publication Date	Feb 7, 2022
Publication Date	2022-02
Deposit Date	Oct 2, 2022
Publicly Available Date	Feb 8, 2023
Journal	Current Neuropharmacology
Print ISSN	1570-159X
Publisher	Bentham Science Publishers
Peer Reviewed	Peer Reviewed
Volume	20
Issue	2
Pages	309-323
DOI	https://doi.org/10.2174/1570159X19666210823103020
Keywords	Curcuminoids; Polymer; PLGA; Cognition; Inflammation; Drug delivery
Public URL	https://hull-repository.worktribe.com/output/3946362