J. M. Rotchell
Ras gene in marine mussels: A molecular level response to petrochemical exposure
Rotchell, J. M.; Rendon-Von Osten, J.; Soares, A. Mn. M.; Lima, I.; Peck, M. R.; Rendón-Von Osten, J.; Soares, A. M. V. M.; Guilhermino, L.; Rotchell, Jeanette
Authors
J. Rendon-Von Osten
A. Mn. M. Soares
I. Lima
M. R. Peck
J. Rendón-Von Osten
A. M. V. M. Soares
L. Guilhermino
Jeanette Rotchell
Abstract
Mussels are susceptible to numerous toxicants and are often employed as bioindicators. This study investigated the status of the ras proto-oncogene in Mytilus galloprovincialis following petrochemical exposure. A M. galloprovincialis homologue of the vertebrate ras gene was isolated, showing conserved sequence in regions of functional importance and a high incidence of polymorphic variation. Mutational damage was investigated in mussels chronically exposed to the water-accommodated fraction of #4 fuel-oil (WAF), and in mussels collected along the NW coast of Portugal in sites with different levels of petrochemical contamination. A ras gene point mutation was identified in the codon 35 of one individual exposed to 12.5% WAF. No mutations were detected in mussels from the WAF control or environmental samples. This represents the first report of a ras gene mutation, experimentally-induced by petrochemical exposure, in an invertebrate species. © 2008 Elsevier Ltd. All rights reserved.
Citation
Lima, I., Peck, M. R., Rendón-Von Osten, J., Soares, A. M. V. M., Guilhermino, L., & Rotchell, J. (2008). Ras gene in marine mussels: A molecular level response to petrochemical exposure. Marine pollution bulletin, 56(4), 633-640. https://doi.org/10.1016/j.marpolbul.2008.01.018
Journal Article Type | Article |
---|---|
Online Publication Date | Mar 7, 2008 |
Publication Date | 2008-04 |
Journal | MARINE POLLUTION BULLETIN |
Print ISSN | 0025-326X |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 56 |
Issue | 4 |
Pages | 633-640 |
DOI | https://doi.org/10.1016/j.marpolbul.2008.01.018 |
Keywords | ras gene Mytilus galloprovincialis mutation biomarker genotoxicity petroleum hydrocarbon polycyclic aromatic-hydrocarbons mytilus-edulis complex dna-adducts mya-arenaria oncogene mutations hemic neoplasia softshell clams macoma-balthica harbor sediment bl |
Public URL | https://hull-repository.worktribe.com/output/400021 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S0025326X0800026X?via%3Dihub |
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