Anticancer Mechanisms of Berberine: A Good Choice for Glioblasto-ma Multiforme Therapy

Bibak, Bahram; Shakeri, Farzaneh; Keshavarzi, Zakieh; Mollazadeh, Hamid; Javid, Hossein; Jalili-Nik, Mohammad; Sathyapalan, Thozhukat; Afshari, Amir R.; Sahebkar, Amirhossein

Abstract

The most typical malignant brain tumor, glioblastoma multiforme (GBM), seems to have a grim outcome, despite the intensive multi-modality interventions. Literature suggests that biologically active phytomolecules may exert anticancer properties by regulating several signaling pathways. Berberine, an isoquinoline alkaloid, has various pharmacological applications to combat severe diseases like cancer. Mechanistically, it inhibits cell proliferation and invasion, suppresses tumor angiogenesis, and induces cell apoptosis. The antitumoral effect of berberine in GBM is increasingly recognized. This review sheds new light on the regulatory signaling mechanisms of berberine in various cancers, proposing its potential role as a therapeutic agent for GBM.

Citation

Bibak, B., Shakeri, F., Keshavarzi, Z., Mollazadeh, H., Javid, H., Jalili-Nik, M., Sathyapalan, T., Afshari, A. R., & Sahebkar, A. (2022). Anticancer Mechanisms of Berberine: A Good Choice for Glioblasto-ma Multiforme Therapy. Current medicinal chemistry, 29(26), 4507-4528. https://doi.org/10.2174/0929867329666220224112811

• Journal Article Type: Review
• Acceptance Date: Mar 3, 2022
• Online Publication Date: Apr 6, 2022
• Publication Date: Apr 4, 2022
• Deposit Date: Nov 6, 2022
• Publicly Available Date: Apr 5, 2023
• Journal: Current Medicinal Chemistry
• Print ISSN: 0929-8673
• Publisher: Bentham Science Publishers
• Peer Reviewed: Peer Reviewed
• Volume: 29
• Issue: 26
• Pages: 4507-4528
• DOI: https://doi.org/10.2174/0929867329666220224112811
• Keywords: Glioblastoma multiforme; Phytomolecules; Berberine; Autophagy; Apoptosis; Malignant brain tumor
• Public URL: https://hull-repository.worktribe.com/output/4018957