The effect of concomitant use of Colony-Stimulating factors on bleomycin pulmonary toxicity – A systematic review and meta-analysis

Mahdi Seyedzadeh Sani, Seyed; Sahranavard, Mehrdad; Jannati Yazdanabad, Mahdi; Seddigh Shamsi, Mohsen; Elyasi, Sepideh; Hooshang Mohammadpour, Amir; Sathyapalan, Thozhukat; Arasteh, Omid; Ghavami, Vahid; Sahebkar, Amirhossein

Abstract

Background: Changes in the incidence of bleomycin pulmonary toxicity (BPT) as a result of adding colony-stimulating factors (CSF) to bleomycin regimens has been investigated in numerous studies. We performed a systematic review and meta-analysis to assess the outcomes of these studies. Methods: A systematic search was performed using Pubmed, Scopus, Web of Science, and Embase on April 2021. Studies evaluating the incidence of BPT in patients receiving bleomycin with and without CSF were included. In addition, meta-analysis was performed by pooling odds ratios using R. Results: Out of 340 obtained records, our qualitative and quantitative analysis included 3234 and 1956 patients from 22 and 14 studies, respectively. The quantitative synthesis showed that addition of CSF significantly increased the risk of BPT incidence (OR = 1.82, 95 % CI: 1.37–2.40, p < 0.0001; I2 = 10.7 %). Subgroup analysis did not show any association between continent, bleomycin dose, cancer type, type of study, and pulmonary function test with BPT incidence. Conclusion: This systematic review and meta-analysis showed that co-administration of CSF with bleomycin increases the incidence of BPT. The physicians need to consider this finding while deciding the best strategy for this cohort of patients.

Citation

Mahdi Seyedzadeh Sani, S., Sahranavard, M., Jannati Yazdanabad, M., Seddigh Shamsi, M., Elyasi, S., Hooshang Mohammadpour, A., …Sahebkar, A. (2022). The effect of concomitant use of Colony-Stimulating factors on bleomycin pulmonary toxicity – A systematic review and meta-analysis. International immunopharmacology, 112, Article 109227. https://doi.org/10.1016/j.intimp.2022.109227

• Journal Article Type: Review
• Acceptance Date: Aug 31, 2022
• Online Publication Date: Sep 10, 2022
• Publication Date: 2022-11
• Deposit Date: Oct 2, 2022
• Publicly Available Date: Sep 11, 2023
• Journal: International Immunopharmacology
• Print ISSN: 1567-5769
• Electronic ISSN: 1878-1705
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 112
• Article Number: 109227
• DOI: https://doi.org/10.1016/j.intimp.2022.109227
• Keywords: Bleomycin; Colony-stimulating factor; Bleomycin pulmonary toxicity
• Public URL: https://hull-repository.worktribe.com/output/4082688