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Protective effects of curcumin on ischemia/reperfusion injury

Mohamadian, Malihe; Parsamanesh, Negin; Chiti, Hossein; Sathyapalan, Thozhukat; Sahebkar, Amirhossein


Malihe Mohamadian

Negin Parsamanesh

Hossein Chiti

Amirhossein Sahebkar


Ischemia/reperfusion (I/R) injury is a term used to describe phenomena connected to the dysfunction of various tissue damage due to reperfusion after ischemic injury. While I/R may result in systemic inflammatory response syndrome or multiple organ dysfunction syndrome, there is still a long way to improve therapeutic outcomes. A number of cellular metabolic and ultrastructural alterations occur by prolonged ischemia. Ischemia increases the expression of proinflammatory gene products and bioactive substances within the endothelium, such as cytokines, leukocytes, and adhesion molecules, even as suppressing the expression of other “protective” gene products and substances, such as thrombomodulin and constitutive nitric oxide synthase (e.g., prostacyclin, nitric oxide [NO]). Curcumin is the primary phenolic pigment derived from turmeric, the powdered rhizome of Curcuma longa. Numerous studies have shown that curcumin has strong antiinflammatory and antioxidant characteristics. It also prevents lipid peroxidation and scavenges free radicals like superoxide anion, singlet oxygen, NO, and hydroxyl. In our study, we highlight the mechanisms of protective effects of curcumin against I/R injury in various organs.


Mohamadian, M., Parsamanesh, N., Chiti, H., Sathyapalan, T., & Sahebkar, A. (2022). Protective effects of curcumin on ischemia/reperfusion injury. Phytotherapy Research,

Journal Article Type Review
Acceptance Date Aug 24, 2022
Online Publication Date Sep 19, 2022
Publication Date 2022
Deposit Date Oct 2, 2022
Publicly Available Date Sep 20, 2023
Journal Phytotherapy Research
Print ISSN 0951-418X
Electronic ISSN 1099-1573
Publisher Wiley
Peer Reviewed Peer Reviewed
Keywords Curcumin; Gastrointestinal system; Heart; Ischemia–reperfusion injury; Kidney; Nervous system; Reproductive organs
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