Protective effects of curcumin on ischemia/reperfusion injury

Mohamadian, Malihe; Parsamanesh, Negin; Chiti, Hossein; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Abstract

Ischemia/reperfusion (I/R) injury is a term used to describe phenomena connected to the dysfunction of various tissue damage due to reperfusion after ischemic injury. While I/R may result in systemic inflammatory response syndrome or multiple organ dysfunction syndrome, there is still a long way to improve therapeutic outcomes. A number of cellular metabolic and ultrastructural alterations occur by prolonged ischemia. Ischemia increases the expression of proinflammatory gene products and bioactive substances within the endothelium, such as cytokines, leukocytes, and adhesion molecules, even as suppressing the expression of other “protective” gene products and substances, such as thrombomodulin and constitutive nitric oxide synthase (e.g., prostacyclin, nitric oxide [NO]). Curcumin is the primary phenolic pigment derived from turmeric, the powdered rhizome of Curcuma longa. Numerous studies have shown that curcumin has strong antiinflammatory and antioxidant characteristics. It also prevents lipid peroxidation and scavenges free radicals like superoxide anion, singlet oxygen, NO, and hydroxyl. In our study, we highlight the mechanisms of protective effects of curcumin against I/R injury in various organs.

Citation

Mohamadian, M., Parsamanesh, N., Chiti, H., Sathyapalan, T., & Sahebkar, A. (2022). Protective effects of curcumin on ischemia/reperfusion injury. Phytotherapy Research, https://doi.org/10.1002/ptr.7620

• Journal Article Type: Review
• Acceptance Date: Aug 24, 2022
• Online Publication Date: Sep 19, 2022
• Publication Date: 2022
• Deposit Date: Oct 2, 2022
• Publicly Available Date: Sep 20, 2023
• Journal: Phytotherapy Research
• Print ISSN: 0951-418X
• Electronic ISSN: 1099-1573
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1002/ptr.7620
• Keywords: Curcumin; Gastrointestinal system; Heart; Ischemia–reperfusion injury; Kidney; Nervous system; Reproductive organs
• Public URL: https://hull-repository.worktribe.com/output/4086151