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Intracranial pressure changes during mouse development

Moazen, Mehran; Alazmani, Ali; Rafferty, Katherine; Liu, Zi-Jun; Gustafson, Jennifer; Cunningham, Michael L.; Fagan, Michael J.; Herring, Susan W.


Mehran Moazen

Ali Alazmani

Katherine Rafferty

Zi-Jun Liu

Jennifer Gustafson

Michael L. Cunningham

Michael J. Fagan

Susan W. Herring


During early stages of postnatal development, pressure from the growing brain as well as cerebrospinal fluid, i.e. intracranial pressure (ICP), load the calvarial bones. It is likely that such loading contributes to the peripheral bone formation at the sutural edges of calvarial bones, especially shortly after birth when the brain is growing rapidly. The aim of this study was to quantify ICP during mouse development. A custom pressure monitoring system was developed and calibrated. It was then used to measure ICP in a total of seventy three wild type mice at postnatal (P) day 3, 10, 20, 31 and 70. Retrospectively, the sample in each age group with the closest ICP to the average value was scanned using micro-computed tomography to estimate cranial growth. ICP increased from 1.33±0.87 mmHg at P3 to 1.92±0.78 mmHg at P10 and 3.60±1.08 mmHg at P20. In older animals, ICP plateaued at about 4 mmHg. There were statistically significant differences between the ICP at the P3 vs. P20, and P10 vs. P20. In the samples that were scanned, intracranial volume and skull length followed a similar pattern of increase up to P20 and then plateaued at older ages. These data are consistent with the possibility of ICP being a contributing factor to bone formation at the sutures during early stages of development. The data can be further used for development and validation of computational models of skull growth.


Moazen, M., Alazmani, A., Rafferty, K., Liu, Z., Gustafson, J., Cunningham, M. L., …Herring, S. W. (2016). Intracranial pressure changes during mouse development. Journal of biomechanics, 49(1), 123-126.

Acceptance Date Nov 10, 2015
Online Publication Date Nov 18, 2015
Publication Date Jan 4, 2016
Deposit Date Mar 4, 2016
Publicly Available Date Mar 4, 2016
Journal Journal of biomechanics
Print ISSN 0021-9290
Electronic ISSN 1873-2380
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 49
Issue 1
Pages 123-126
Keywords Intracranial pressure, Skull, Suture, Biomechanics, Development
Public URL
Publisher URL
Additional Information This article is maintained by: Elsevier; Article Title: Intracranial pressure changes during mouse development; Journal Title: Journal of Biomechanics; CrossRef DOI link to publisher maintained version:; Content Type: article; Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.


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