Professor Jeanette Rotchell J.Rotchell@hull.ac.uk
Professor
Professor Jeanette Rotchell J.Rotchell@hull.ac.uk
Professor
Elena Cubero-Leon
A. Mirel Puinean
Pierre Labadie
Corina Ciocan
Naoki Itoh
Mitsuyo Kishida
Makoto Osada
Christophe Minier
Elizabeth M. Hill
Professor Jeanette Rotchell J.Rotchell@hull.ac.uk
Professor
Members of the vertebrate CYP3A subfamily are involved in the metabolism of steroids and a wide range of xenobiotics. In this study two CYP3A- like mRNAs have been isolated from the mussel (Mytilus edulis), and their seasonal expression profile and modulation by estrogens examined. Sexual dimorphism of CYP3A- like mRNA expression was not observed in mussel gonads of individuals collected throughout a year. Nevertheless, natural variation in gonadal CYP3A- like mRNA expression was observed, with highest levels of CYP3A isoform1 and lowest levels of CYP3A isoform2 mRNA during the maturation and spawning season. Exposure to a 10% sewage treatment works extract did not result in any significant changes in mRNA expression of CYP3A-like. In contrast, exposure to E2 (200ng/L) and TBT (100ng/L) significantly down-regulated the expression of CYP3A- like isoform1 but not CYP3A-like isoform2 suggesting differential regulation. Understanding xenobiotic metabolism pathways in aquatic invertebrates.
Cubero-Leon, E., Puinean, A. M., Labadie, P., Ciocan, C., Itoh, N., Kishida, M., …Rotchell, J. M. (2012). Two CYP3A-like genes in the marine mussel Mytilus edulis: mRNA expression modulation following short-term exposure to endocrine disruptors. Marine environmental research, 74, (32-39). doi:10.1016/j.marenvres.2011.11.012. ISSN 0141-1136
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 21, 2011 |
Online Publication Date | Dec 7, 2012 |
Publication Date | 2012-03 |
Journal | Marine environmental research |
Print ISSN | 0141-1136 |
Electronic ISSN | 1879-0291 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 74 |
Pages | 32-39 |
DOI | https://doi.org/10.1016/j.marenvres.2011.11.012 |
Keywords | Pollution; Ecotoxicology; Mussel; CYP3A |
Public URL | https://hull-repository.worktribe.com/output/417621 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S0141113611001644?via%3Dihub |
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