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A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease

Sardou, Hossein Shahdadi; Vosough, Paria Rahnama; Abbaspour, Mohammadreza; Akhgari, Abbas; Sathyapalan, Thozhukat; Sahebkar, Amirhossein


Hossein Shahdadi Sardou

Paria Rahnama Vosough

Mohammadreza Abbaspour

Abbas Akhgari

Amirhossein Sahebkar


Synthetic drugs and monoclonal antibodies are the typical treatments to combat inflammatory bowel disease (IBD). However, side effects are present when these treatments are used, and their continued application could be restricted by the high relapse rate of the disease. One potential alternative to these treatments is the use of plant-derived products. The use curcumin is one such treatment option that has seen an increase in usage in treating IBD. Curcumin is derived from a rhizome of turmeric (Curcuma longa), and the results of studies on the use of curcumin to treat IBD are promising. These studies suggest that curcumin interacts with cellular targets such as NF-κB, JAKs/STATs, MAPKs, TNF-α, IL-6, PPAR, and TRPV1 and may reduce the progression of IBD. Potentially, curcumin can be used as a therapeutic agent for patients with IBD when it reduces the incidence of clinical relapse. This review discusses the strategies utilized in designing and developing an oral colonic delivery dosage form of curcumin.


Sardou, H. S., Vosough, P. R., Abbaspour, M., Akhgari, A., Sathyapalan, T., & Sahebkar, A. (in press). A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease. Inflammopharmacology,

Journal Article Type Review
Acceptance Date Jan 19, 2023
Online Publication Date Feb 9, 2023
Deposit Date Feb 18, 2023
Publicly Available Date Feb 10, 2024
Journal Inflammopharmacology
Print ISSN 0925-4692
Electronic ISSN 1568-5608
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Keywords Curcumin; IBD; Gastrointestinal tract; Colon delivery; Microparticles; Nanoparticles
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