A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease

Sardou, Hossein Shahdadi; Vosough, Paria Rahnama; Abbaspour, Mohammadreza; Akhgari, Abbas; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Abstract

Synthetic drugs and monoclonal antibodies are the typical treatments to combat inflammatory bowel disease (IBD). However, side effects are present when these treatments are used, and their continued application could be restricted by the high relapse rate of the disease. One potential alternative to these treatments is the use of plant-derived products. The use curcumin is one such treatment option that has seen an increase in usage in treating IBD. Curcumin is derived from a rhizome of turmeric (Curcuma longa), and the results of studies on the use of curcumin to treat IBD are promising. These studies suggest that curcumin interacts with cellular targets such as NF-κB, JAKs/STATs, MAPKs, TNF-α, IL-6, PPAR, and TRPV1 and may reduce the progression of IBD. Potentially, curcumin can be used as a therapeutic agent for patients with IBD when it reduces the incidence of clinical relapse. This review discusses the strategies utilized in designing and developing an oral colonic delivery dosage form of curcumin.

Citation

Sardou, H. S., Vosough, P. R., Abbaspour, M., Akhgari, A., Sathyapalan, T., & Sahebkar, A. (in press). A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease. Inflammopharmacology, https://doi.org/10.1007/s10787-023-01140-0

• Journal Article Type: Review
• Acceptance Date: Jan 19, 2023
• Online Publication Date: Feb 9, 2023
• Deposit Date: Feb 18, 2023
• Publicly Available Date: Feb 10, 2024
• Journal: Inflammopharmacology
• Print ISSN: 0925-4692
• Electronic ISSN: 1568-5608
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1007/s10787-023-01140-0
• Keywords: Curcumin; IBD; Gastrointestinal tract; Colon delivery; Microparticles; Nanoparticles
• Public URL: https://hull-repository.worktribe.com/output/4202275