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Synthesis of components to form linked multi-metal constructs : potential MRI/optical contrast agents

Al-Yassiry, Mustafa M. A.


Mustafa M. A. Al-Yassiry


Stephen J. Archibald

Benjamin P. Burke


Azamacrocyclic chelators with coordinating pendant arms can form complexes with lanthanide(lll) ions offering a high level of kinetic and thermodynamic stability. There are many potentially useful applications of these complexes in areas such as magnetic resonance imaging (MRI) contrast agents, or luminescent imaging agents dependent on the incorporated metal centre (possible examples include gadolinium(lll), europium(lll) or terbium(lll)).

The synthesis and characterisation of multi-metallic metal complexes as potential imaging agents have been carried out. A series of novel chelators designed to coordinate lanthanide ions (Gd³⁺, Eu³⁺, Tb³⁺, y³⁺) based on the known D03A chelator have been synthesised bearing various heterocyclic pendent arms (pyridine, pyrazine, pyrimidine), which can act as chromophore groups or as linking units to form multi-metallic species. NMR and potentiometric titrations of the ligands and the lanthanide complexes have been investigated to determine the protonation states across a pH range. The relaxometric properties have been studied for gadolinium(lll) complexes of the synthesised chelators showing high relaxivity rates for both T1 (up to 51.8 mM⁻¹ s⁻¹) and T2 (up to 21.6 mM⁻¹ s⁻¹).


Al-Yassiry, M. M. A. (2015). Synthesis of components to form linked multi-metal constructs : potential MRI/optical contrast agents. (Thesis). University of Hull. Retrieved from

Thesis Type Thesis
Deposit Date Feb 7, 2017
Publicly Available Date Feb 23, 2023
Keywords Chemistry
Public URL
Additional Information Department of Chemistry, The University of Hull
Award Date Dec 1, 2015


Thesis (42.4 Mb)

Copyright Statement
© 2015 Al-Yassiry, Mustafa M. A. All rights reserved. No part of this publication may be reproduced without the written permission of the copyright holder.

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