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Low dose cabergoline for hyperprolactinaemia is not associated with clinically significant valvular heart disease

Rigby, A. S; Wakil, Ammar; Rigby, Alan S.; Kallvikbacka-Bennett, Anne; Clark, Andrew L.; Atkin, S. L; Rigby, Alan; Kallvikbacka-Bennett, Anna; Atkin, Stephen L.


A. S Rigby

Ammar Wakil

Anne Kallvikbacka-Bennett

Andrew L. Clark

S. L Atkin

Anna Kallvikbacka-Bennett

Stephen L. Atkin


OBJECTIVE: Recent trials suggest that using ergot-derived dopamine agonists such as cabergoline in the treatment of Parkinson's disease is associated with an increased risk of valvular heart disease. However, the dose of cabergoline used to treat hyperprolactinaemia is considerably less than that used in Parkinson's disease. DESIGN AND METHODS: A cross-sectional comparative assessment. Forty-four patients treated with cabergoline for hyperprolactinaemia underwent transthoracic echocardiography and were compared with 566 sequential subjects complaining of palpitations, taken from a contemporary echocardiography database. RESULTS: The mean cumulative dose of cabergoline in the cases was 311 mg. There was no significant, severe or moderate, right- or left-sided valvular regurgitation in either group. Left heart: in the mitral and aortic valves, the rate of mild and trivial valvular regurgitation was not different between the two groups. Right heart: mild tricuspid and pulmonary regurgitation on colour Doppler alone was increased significantly in the cabergoline group, odds ratios of 3.1 and 7.8 respectively (95% confidence interval 1.0-9.6 and 0.8-78.4, P=0.04 and P<0.0001 respectively). CONCLUSION: Cabergoline at doses sufficient to suppress hyperprolactinaemia for a period of 3-4 years is not associated with an increased risk of clinically significant valvular regurgitation


Wakil, A., Rigby, A. S., Clark, A. L., Kallvikbacka-Bennett, A., & Atkin, S. L. (2008). Low dose cabergoline for hyperprolactinaemia is not associated with clinically significant valvular heart disease. European journal of endocrinology, 159(4), R11-R14.

Journal Article Type Article
Acceptance Date Jul 10, 2008
Online Publication Date Jul 30, 2008
Publication Date Oct 1, 2008
Journal Eur.J.Endocrinol.
Print ISSN 0804-4643
Electronic ISSN 1479-683X
Publisher BioScientifica
Peer Reviewed Peer Reviewed
Volume 159
Issue 4
Pages R11-R14
Keywords administration & dosage; Adult; agonists; Cross-Sectional Studies; Databases,Factual; Disease; Dopamine; Dopamine Agonists; drug therapy; Echocardiography; Echocardiography,Doppler,Color; epidemiology; Ergolines; Female; Heart; Heart Valve Diseases; Human
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