Alsu I. Zamaleeva
Cyborg cells: functionalisation of living cells with polymers and nanomaterials
Zamaleeva, Alsu I.; Fakhrullin, Rawil F.; Minullina, Renata T.; Konnova, Svetlana A.; Paunov, Vesselin N.
Rawil F. Fakhrullin
Renata T. Minullina
Svetlana A. Konnova
Professor Vesselin Paunov V.N.Paunov@hull.ac.uk
Professor of Physical Chemistry and Advanced Materials
Living cells interfaced with a range of polyelectrolyte coatings, magnetic and noble metal nanoparticles, hard mineral shells and other complex nanomaterials can perform functions often completely different from their original specialisation. Such “cyborg cells” are already finding a range of novel applications in areas like whole cell biosensors, bioelectronics, toxicity microscreening, tissue engineering, cell implant protection and bioanalytical chemistry. In this tutorial review, we describe the development of novel methods for functionalisation of cells with polymers and nanoparticles and comment on future advances in this technology in the light of other literature approaches. We review recent studies on the cell viability and function upon direct deposition of nanoparticles, coating with polyelectrolytes, polymer assisted assembly of nanomaterials and hard shells on the cell surface. The cell toxicity issues are considered for many practical applications in terms of possible adverse effects of the deposited polymers, polyelectrolytes and nanoparticles on the cell surface.
|Journal Article Type||Article|
|Journal||CHEMICAL SOCIETY REVIEWS|
|Publisher||Royal Society of Chemistry|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Fakhrullin, R. F., Zamaleeva, A. I., Minullina, R. T., Konnova, S. A., & Paunov, V. N. (2012). Cyborg cells: functionalisation of living cells with polymers and nanomaterials. Chemical Society Reviews, 41(11), 4189. https://doi.org/10.1039/c2cs15264a|
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