Association of C-reactive protein with histological, elastographic, and sonographic indices of non-alcoholic fatty liver disease in individuals with severe obesity

Jamialahmadi, Tannaz; Bo, Simona; Abbasifard, Mitra; Sathyapalan, Thozhukat; Jangjoo, Ali; Moallem, Seyed Adel; Almahmeed, Wael; Ashari, Sorour; Johnston, Thomas P.; Sahebkar, Amirhossein

Abstract

BACKGROUND: Inflammation is critical in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). hs-CRP, an inflammatory marker, is considered one of the prognostic predictors of hepatic damage progression in NAFLD in some studies. METHODS: We assessed the concordance of hs-CRP concentrations and liver steatosis, steatohepatitis, and fibrosis based on elastography, sonography and liver biopsy findings in patients with severe obesity undergoing bariatric surgery. RESULTS: Among 90 patients, 56.7% showed steatohepatitis and 8.9% severe fibrosis. Hs-CRP were significantly associated with liver histology in an adjusted regression model (OR 1.155, 95% CI 1.029-1.297, p = 0.014; OR 1.155, 1.029-1.297, p = 0.014; OR 1.130, 1.017-1.257, p = 0.024 for steatosis, steatohepatitis, and fibrosis, respectively). The ROC curve, a cutoff of hs-CRP = 7 mg/L, showed a reasonable specificity (76%) for detecting biopsy-proven fibrosis and steatosis. CONCLUSION: hs-CRP was associated with any degree of histologically diagnosed liver damage, and it had a reasonable specificity for predicting biopsy-proven steatosis and fibrosis in obese individuals. Further studies are needed to identify non-invasive biomarkers that could predict NALFD progression due to the relevant health risks linked to liver fibrosis.

Citation

Jamialahmadi, T., Bo, S., Abbasifard, M., Sathyapalan, T., Jangjoo, A., Moallem, S. A., …Sahebkar, A. (2023). Association of C-reactive protein with histological, elastographic, and sonographic indices of non-alcoholic fatty liver disease in individuals with severe obesity. Journal of Health, Population and Nutrition, 42(1), Article 30. https://doi.org/10.1186/s41043-023-00372-8

• Journal Article Type: Review
• Acceptance Date: Mar 31, 2023
• Online Publication Date: Apr 7, 2023
• Publication Date: Apr 7, 2023
• Deposit Date: May 21, 2023
• Publicly Available Date: May 22, 2023
• Journal: Journal of health, population, and nutrition
• Electronic ISSN: 2072-1315
• Publisher: BioMed Central
• Peer Reviewed: Peer Reviewed
• Volume: 42
• Issue: 1
• Article Number: 30
• DOI: https://doi.org/10.1186/s41043-023-00372-8
• Keywords: Fatty liver; Steatohepatitis; Liver fibrosis; Fatty liver; Biopsy; Elastography; Inflammation
• Public URL: https://hull-repository.worktribe.com/output/4267871