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Electrical stimulation vs. standard care for chronic ulcer healing: a systematic review and meta-analysis of randomised controlled trials

Barnes, Rachel; Shahin, Yousef; Gohil, Risha; Chetter, Ian

Authors

Rachel Barnes

Yousef Shahin

Risha Gohil



Abstract

Background

We conducted a systematic review to investigate the effect of electrical stimulation on ulcer healing compared to usual treatment and/or sham stimulation. This systematic review also aimed to investigate the effect of different types of electrical stimulation on ulcer size reduction.
Materials and Methods

MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) were searched from inception to October 2013 on randomised controlled trials (RCTs), in English and on human subjects, which assessed the effect of electrical stimulation on ulcer size as compared to standard care and/or sham stimulation. Data from included RCTs were pooled with use of fixed and random effects meta-analysis of the weighted mean change differences between the comparator groups. Heterogeneity across studies was assessed with the I2 statistic.

Results

Twenty-one studies were eligible for inclusion in the meta-analysis. In six trials (n = 210), electrical stimulation improved mean percentage change in ulcer size over total studies periods by 24·62%, 95% confidence interval (CI) 19·98–29·27, P < 0·00001 with no heterogeneity. In three trials (n = 176), electrical stimulation insignificantly improved mean weekly change in ulcer size by 1·64%, 95% (CI) −3·81 to 7·09, P = 0·56 with significant heterogeneity (I2 = 96%, P < 0·00001). In six trials (n = 266), electrical stimulation decreased ulcer size by 2·42 cm2, 95% (CI) 1·66–3·17, P < 0·00001, with significant heterogeneity. In one trial (n = 16), electrical stimulation also insignificantly improved the mean daily percentage change in ulcer size by 0·63%, 95% (CI) −0·12 to 1·37, P = 0·10, with significant heterogeneity.

Conclusions

Electrical stimulation appears to increase the rate of ulcer healing and may be superior to standard care for ulcer treatment.

Citation

Barnes, R., Shahin, Y., Gohil, R., & Chetter, I. (2014). Electrical stimulation vs. standard care for chronic ulcer healing: a systematic review and meta-analysis of randomised controlled trials. European Journal of Clinical Investigation, 44(4), 429-440. https://doi.org/10.1111/eci.12244

Journal Article Type Article
Acceptance Date Apr 30, 2014
Online Publication Date Mar 12, 2014
Publication Date 2014-04
Journal European Journal of Clinical Investigation
Print ISSN 0014-2972
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 44
Issue 4
Pages 429-440
DOI https://doi.org/10.1111/eci.12244
Keywords Clinical Biochemistry; Biochemistry; General Medicine
Public URL https://hull-repository.worktribe.com/output/432563
Publisher URL https://onlinelibrary.wiley.com/doi/full/10.1111/eci.12244