C-reactive protein and the Framingham coronary risk score in patients newly diagnosed with intermittent claudication: a prospective study

Shahin, Yousef; Hatfield, Josie; Chetter, Ian

Abstract

Objective: To investigate the relationship between serum C-reactive protein (CRP) levels and the calculated 10-year Framingham risk score (FRS) in patients newly diagnosed with intermittent claudication. Methods: Serum CRP levels were measured in 90 patients newly diagnosed with intermittent claudication over a 12-month period. In all, 76 patients (53 males [70%], mean age 63.3±9.3) were included in the analysis. Results: Log-transformed CRP levels significantly correlated with total FRS (r=.34, P=.002). Participants were divided into 4 groups according to log-CRP levels. Analysis of variance showed a statistically significant difference between the 4 groups in terms of mean FRS, P=.003. Post hoc comparisons indicated that group 1 was significantly different from group 4, P=.002. Analysis of covariance showed a significant difference between the 4 groups of log-CRP levels in terms of mean FRS, P=.008. Conclusion: There is an increased 10-year risk of coronary heart disease associated with increased plasma concentration of CRP in patients newly diagnosed with intermittent claudication.

Citation

Shahin, Y., Hatfield, J., & Chetter, I. (2012). C-reactive protein and the Framingham coronary risk score in patients newly diagnosed with intermittent claudication: a prospective study. Vascular and endovascular surgery, 46(3), 242-245. https://doi.org/10.1177/1538574412438062

• Journal Article Type: Article
• Acceptance Date: Apr 1, 2012
• Publication Date: 2012-04
• Journal: Vascular and Endovascular Surgery
• Print ISSN: 1538-5744
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 46
• Issue: 3
• Pages: 242-245
• DOI: https://doi.org/10.1177/1538574412438062
• Keywords: Surgery; Cardiology and Cardiovascular Medicine; General Medicine
• Public URL: https://hull-repository.worktribe.com/output/432591