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Molecular changes in skin pigmented lesions of the coral trout Plectropomus leopardus

Lerebours, Adelaide; Chapman, Emma C.; Rotchell, Jeanette M.; Heupel, Michelle R.; Sweet, Michael J.

Authors

Adelaide Lerebours

Emma C. Chapman

Michelle R. Heupel

Michael J. Sweet



Abstract

© 2016 Elsevier Ltd A high prevalence of skin pigmented lesions of 15% was recently reported in coral trout Plectropomus leopardus, a commercially important marine fish, inhabiting the Great Barrier Reef. Herein, fish were sampled at two offshore sites, characterised by high and low lesion prevalence. A transcriptomic approach using the suppressive subtractive hybridisation (SSH) method was used to analyse the differentially expressed genes between lesion and normal skin samples. Transcriptional changes of 14 genes were observed in lesion samples relative to normal skin samples. These targeted genes encoded for specific proteins which are involved in general cell function but also in different stages disrupted during the tumourigenesis process of other organisms, such as cell cycling, cell proliferation, skeletal organisation and cell migration. The results highlight transcripts that are associated with the lesion occurrence, contributing to a better understanding of the molecular aetiology of this coral trout skin disease.

Journal Article Type Article
Publication Date Sep 1, 2016
Journal Marine environmental research
Print ISSN 0141-1136
Electronic ISSN 1879-0291
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 120
Pages 130-135
Institution Citation Lerebours, A., Chapman, E. C., Rotchell, J. M., Heupel, M. R., & Sweet, M. J. (2016). Molecular changes in skin pigmented lesions of the coral trout Plectropomus leopardus. Marine environmental research, 120, (130-135). doi:10.1016/j.marenvres.2016.07.009. ISSN 0141-1136
DOI https://doi.org/10.1016/j.marenvres.2016.07.009
Keywords Fish, Skin lesion, Melanosis, Gene expression
Publisher URL http://www.sciencedirect.com/science/article/pii/S0141113616301271
Copyright Statement ©2017, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

Authors' accepted manuscript of article published in: Marine environmental research, 2016, v.120.
Additional Information This article is maintained by: Elsevier; Article Title: Molecular changes in skin pigmented lesions of the coral trout Plectropomus leopardus; Journal Title: Marine Environmental Research; CrossRef DOI link to publisher maintained version: http://dx.doi.org/10.1016/j.marenvres.2016.07.009; Content Type: article; Copyright: © 2016 Elsevier Ltd. All rights reserved.

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Copyright Statement
©2017, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

Authors' accepted manuscript of article published in: Marine environmental research, 2016, v.120.





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