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Molecular changes in skin pigmented lesions of the coral trout Plectropomus leopardus

Lerebours, Adelaide; Chapman, Emma C.; Rotchell, Jeanette M.; Heupel, Michelle R.; Sweet, Michael J.


Adelaide Lerebours

Emma C. Chapman

Michelle R. Heupel

Michael J. Sweet


© 2016 Elsevier Ltd A high prevalence of skin pigmented lesions of 15% was recently reported in coral trout Plectropomus leopardus, a commercially important marine fish, inhabiting the Great Barrier Reef. Herein, fish were sampled at two offshore sites, characterised by high and low lesion prevalence. A transcriptomic approach using the suppressive subtractive hybridisation (SSH) method was used to analyse the differentially expressed genes between lesion and normal skin samples. Transcriptional changes of 14 genes were observed in lesion samples relative to normal skin samples. These targeted genes encoded for specific proteins which are involved in general cell function but also in different stages disrupted during the tumourigenesis process of other organisms, such as cell cycling, cell proliferation, skeletal organisation and cell migration. The results highlight transcripts that are associated with the lesion occurrence, contributing to a better understanding of the molecular aetiology of this coral trout skin disease.


Lerebours, A., Chapman, E. C., Rotchell, J. M., Heupel, M. R., & Sweet, M. J. (2016). Molecular changes in skin pigmented lesions of the coral trout Plectropomus leopardus. Marine environmental research, 120, 130-135.

Journal Article Type Article
Acceptance Date Jul 16, 2016
Online Publication Date Jul 28, 2016
Publication Date Sep 1, 2016
Deposit Date Jul 21, 2016
Publicly Available Date Oct 27, 2022
Journal Marine environmental research
Print ISSN 0141-1136
Electronic ISSN 1879-0291
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 120
Pages 130-135
Keywords Fish, Skin lesion, Melanosis, Gene expression
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Additional Information This article is maintained by: Elsevier; Article Title: Molecular changes in skin pigmented lesions of the coral trout Plectropomus leopardus; Journal Title: Marine Environmental Research; CrossRef DOI link to publisher maintained version:; Content Type: article; Copyright: © 2016 Elsevier Ltd. All rights reserved.


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©2017, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license<br /> <br /> Authors' accepted manuscript of article published in: Marine environmental research, 2016, v.120.

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