Molecular changes in skin pigmented lesions of the coral trout Plectropomus leopardus
Lerebours, Adelaide; Chapman, Emma C.; Rotchell, Jeanette M.; Heupel, Michelle R.; Sweet, Michael J.
Emma C. Chapman
Professor Jeanette Rotchell J.Rotchell@hull.ac.uk
Professor and Associate Dean for Research and Enterprise
Michelle R. Heupel
Michael J. Sweet
© 2016 Elsevier Ltd A high prevalence of skin pigmented lesions of 15% was recently reported in coral trout Plectropomus leopardus, a commercially important marine fish, inhabiting the Great Barrier Reef. Herein, fish were sampled at two offshore sites, characterised by high and low lesion prevalence. A transcriptomic approach using the suppressive subtractive hybridisation (SSH) method was used to analyse the differentially expressed genes between lesion and normal skin samples. Transcriptional changes of 14 genes were observed in lesion samples relative to normal skin samples. These targeted genes encoded for specific proteins which are involved in general cell function but also in different stages disrupted during the tumourigenesis process of other organisms, such as cell cycling, cell proliferation, skeletal organisation and cell migration. The results highlight transcripts that are associated with the lesion occurrence, contributing to a better understanding of the molecular aetiology of this coral trout skin disease.
Lerebours, A., Chapman, E. C., Rotchell, J. M., Heupel, M. R., & Sweet, M. J. (2016). Molecular changes in skin pigmented lesions of the coral trout Plectropomus leopardus. Marine environmental research, 120, 130-135. https://doi.org/10.1016/j.marenvres.2016.07.009
|Journal Article Type||Article|
|Acceptance Date||Jul 16, 2016|
|Online Publication Date||Jul 28, 2016|
|Publication Date||Sep 1, 2016|
|Deposit Date||Jul 21, 2016|
|Publicly Available Date||Oct 27, 2022|
|Journal||Marine environmental research|
|Peer Reviewed||Peer Reviewed|
|Keywords||Fish, Skin lesion, Melanosis, Gene expression|
|Additional Information||This article is maintained by: Elsevier; Article Title: Molecular changes in skin pigmented lesions of the coral trout Plectropomus leopardus; Journal Title: Marine Environmental Research; CrossRef DOI link to publisher maintained version: http://dx.doi.org/10.1016/j.marenvres.2016.07.009; Content Type: article; Copyright: © 2016 Elsevier Ltd. All rights reserved.|
Publisher Licence URL
©2017, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/<br /> <br /> Authors' accepted manuscript of article published in: Marine environmental research, 2016, v.120.
You might also like
Exposure to low pH induces molecular level changes in the marine worm, Platynereis dumerilii
Effects of low seawater pH on the marine polychaete Platynereis dumerilii