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Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial

Sathyapalan, Thozhukat; Aye, Mo; Rigby, Alan S.; Fraser, William D.; Thatcher, Natalie J.; Kilpatrick, Eric S.; Atkin, Stephen L.

Authors

Thozhukat Sathyapalan

Mo Aye

Alan S. Rigby

William D. Fraser

Natalie J. Thatcher

Eric S. Kilpatrick

Stephen L. Atkin



Abstract

Menopausal estrogen loss leads to an increased bone loss. Soy isoflavones can act as selective estrogen receptor modulators, their role in bone turnover is unclear. The primary outcome was assessing changes in plasma bone turnover markers. The secondary outcomes were assessing changes in cardiovascular risk markers including insulin resistance, blood pressure, and lipid profile. We performed a double-blind randomized parallel study in which 200 women within 2 years after the onset of their menopause were randomized to 15 g soy protein with 66 mg isoflavone (SPI) or 15 g soy protein alone (SP), daily for 6 months. There was a significant reduction in type I collagen crosslinked beta C-telopeptide (βCTX) (bone-resorption marker) with SPI supplementation (0.40 ± 0.17 versus 0.15 ± 0.09 μg/L; p < 0.01) compared to SP supplementation (0.35 ± 0.12 versus 0.35 ± 0.13 μg/L; p = 0.92) after 6 months. There was also a significant reduction in type I procollagen-N-propeptide (P1NP) (bone formation marker) with SPI supplementation (50.5 ± 25.0 versus 34.3 ± 17.6 μg/L; p < 0.01), more marked between 3 and 6 months. Following SPI there was a significant reduction in fasting glucose, fasting insulin, insulin resistance, and systolic blood pressure whereas no significant changes in these parameters was observed with SP. There were no significant changes in fasting lipid profile and diastolic blood pressure with either preparation. There was a significant increase in TSH and reduction in free thyroxine (p < 0.01) with SPI supplementation though free tri-iodothyronine was unchanged. In conclusion, soy protein with isoflavones may confer a beneficial effect on bone health, analogous to the mode of action of antiresorptive agents, albeit to a less magnitude. There was a significant improvement of cardiovascular risk markers, but a significant increase in TSH and reduction in free thyroxine after SPI supplementation indicating a detrimental effect on thyroid function.

Citation

Sathyapalan, T., Aye, M., Rigby, A. S., Fraser, W. D., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2017). Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial. Journal of Bone and Mineral Research, 32(1), 157-164. https://doi.org/10.1002/jbmr.2927

Journal Article Type Article
Acceptance Date Jul 21, 2016
Online Publication Date Sep 6, 2016
Publication Date 2017-01
Deposit Date Aug 1, 2016
Publicly Available Date Sep 6, 2016
Journal Journal of bone and mineral research
Print ISSN 0884-0431
Electronic ISSN 1523-4681
Publisher American Society for Bone and Mineral Research
Peer Reviewed Peer Reviewed
Volume 32
Issue 1
Pages 157-164
DOI https://doi.org/10.1002/jbmr.2927
Keywords Biochemical markers of bone turnover < bone modeling and remodeling, Menopause, Nutrition, Clinical trials
Public URL https://hull-repository.worktribe.com/output/441923
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/jbmr.2927/abstract
Copyright Statement ©2017 University of Hull

Authors' accepted manuscript of article: Sathyapalan, T., Aye, M., Rigby, A. S., Fraser, W. D., Thatcher, N. J., Kilpatrick, E. S. and Atkin, S. L. (2017), Soy Reduces Bone Turnover Markers in Women During Early Menopause: A Randomized Controlled Trial. J Bone Miner Res, 32: 157–164. doi:10.1002/jbmr.2927
Additional Information Authors' accepted manuscript of article: Sathyapalan, T., Aye, M., Rigby, A. S., Fraser, W. D., Thatcher, N. J., Kilpatrick, E. S. and Atkin, S. L. (2017), Soy Reduces Bone Turnover Markers in Women During Early Menopause: A Randomized Controlled Trial. J Bone Miner Res, 32: 157–164. doi:10.1002/jbmr.2927

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Copyright Statement
©2017 University of Hull

Authors' accepted manuscript of article: Sathyapalan, T., Aye, M., Rigby, A. S., Fraser, W. D., Thatcher, N. J., Kilpatrick, E. S. and Atkin, S. L. (2017), Soy Reduces Bone Turnover Markers in Women During Early Menopause: A Randomized Controlled Trial. J Bone Miner Res, 32: 157–164. doi:10.1002/jbmr.2927



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