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Fracture of bone tissue: The 'hows' and the 'whys'

Gupta, H. S.; Zioupos, P.


H. S. Gupta


The mechanical performance of bone is of paramount importance for the quality of life we experience. The structural integrity of bone, its hierarchical structure, organisation and its physicochemical constitution, all influence its ability to withstand loads, such as those seen occasionally in everyday life loading scenarios, which are either above the norm, prolonged, or repetitive. The present review explores three interconnected areas of research where significant progress has been made lately: (i) The recorded mechanical behaviour of bone and the way it fails; (ii) the inner architecture, organisational, hierarchical structure of bone tissue; and (iii) the bone properties at the micro/nanostructural and biophysical level. Exercising a line of thought along a structure/function based argument we advance from 'how' bone fractures to 'why' it fractures, and we seek to obtain a fresh insight in this field. © 2008 IPEM.


Gupta, H. S., & Zioupos, P. (2008). Fracture of bone tissue: The 'hows' and the 'whys'. Medical engineering & physics, 30(10), 1209-1226.

Journal Article Type Article
Online Publication Date Oct 31, 2008
Publication Date 2008-12
Deposit Date Oct 24, 2023
Journal Medical Engineering and Physics
Print ISSN 1350-4533
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 30
Issue 10
Pages 1209-1226
Public URL