Skip to main content

Research Repository

Advanced Search

X-ray diffraction from bone employing annular and semi-annular beams

Dicken, A. J.; Evans, J. P.O.; Rogers, K. D.; Stone, N.; Greenwood, C.; Godber, S. X.; Prokopiou, D.; Clement, J. G.; Lyburn, I. D.; Martin, R. M.; Zioupos, P.

Authors

A. J. Dicken

J. P.O. Evans

K. D. Rogers

N. Stone

C. Greenwood

S. X. Godber

D. Prokopiou

J. G. Clement

I. D. Lyburn

R. M. Martin



Abstract

There is a compelling need for accurate, low cost diagnostics to identify osteo-tissues that are associated with a high risk of fracture within an individual. To satisfy this requirement the quantification of bone characteristics such as 'bone quality' need to exceed that provided currently by densitometry. Bone mineral chemistry and microstructure can be determined from coherent x-ray scatter signatures of bone specimens. Therefore, if these signatures can be measured, in vivo, to an appropriate accuracy it should be possible by extending terms within a fracture risk model to improve fracture risk prediction. In this preliminary study we present an examination of a new x-ray diffraction technique that employs hollow annular and semi-annular beams to measure aspects of 'bone quality'. We present diffractograms obtained with our approach from ex vivo bone specimens at Mo K and W K energies. Primary data is parameterized to provide estimates of bone characteristics and to indicate the precision with which these can be determined.

Citation

Dicken, A. J., Evans, J. P., Rogers, K. D., Stone, N., Greenwood, C., Godber, S. X., Prokopiou, D., Clement, J. G., Lyburn, I. D., Martin, R. M., & Zioupos, P. (2015). X-ray diffraction from bone employing annular and semi-annular beams. Physics in Medicine and Biology, 60(15), 5803-5812. https://doi.org/10.1088/0031-9155/60/15/5803

Journal Article Type Article
Acceptance Date Jun 8, 2015
Online Publication Date Jul 10, 2015
Publication Date Aug 7, 2015
Deposit Date Oct 24, 2023
Publicly Available Date Nov 13, 2023
Journal Physics in Medicine and Biology
Print ISSN 0031-9155
Electronic ISSN 1361-6560
Publisher IOP Publishing
Peer Reviewed Peer Reviewed
Volume 60
Issue 15
Pages 5803-5812
DOI https://doi.org/10.1088/0031-9155/60/15/5803
Public URL https://hull-repository.worktribe.com/output/4424535

Files

Published article (1.2 Mb)
PDF

Publisher Licence URL
http://creativecommons.org/licenses/by/3.0

Copyright Statement
© 2015 Institute of Physics and Engineering in Medicine.
Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.





You might also like



Downloadable Citations