Localized tissue mineralization regulated by bone remodelling: A computational approach

Berli, Marcelo; Borau, Carlos; Decco, Oscar; Adams, George; Cook, Richard B.; Aznar, José Manuel García; Zioupos, Peter

Abstract

Bone is a living tissue whose main mechanical function is to provide stiffness, strength and protection to the body. Both stiffness and strength depend on the mineralization of the organic matrix, which is constantly being remodelled by the coordinated action of the bone multicellular units (BMUs). Due to the dynamics of both remodelling and mineralization, each sample of bone is composed of structural units (osteons in cortical and packets in cancellous bone) created at different times, therefore presenting different levels of mineral content. In this work, a computational model is used to understand the feedback between the remodelling and the mineralization processes under different load conditions and bone porosities. This model considers that osteoclasts primarily resorb those parts of bone closer to the surface, which are younger and less mineralized than older inner ones. Under equilibrium loads, results show that bone volumes with both the highest and the lowest levels of porosity (cancellous and cortical respectively) tend to develop higher levels of mineral content compared to volumes with intermediate porosity, thus presenting higher material densities. In good agreement with recent experimental measurements, a boomerang-like pattern emerges when plotting apparent density at the tissue level versus material density at the bone material level. Overload and disuse states are studied too, resulting in a translation of the apparent-material density curve. Numerical results are discussed pointing to potential clinical applications.

Citation

Berli, M., Borau, C., Decco, O., Adams, G., Cook, R. B., Aznar, J. M. G., & Zioupos, P. (2017). Localized tissue mineralization regulated by bone remodelling: A computational approach. PLoS ONE, 12(3), Article e0173228. https://doi.org/10.1371/journal.pone.0173228

• Journal Article Type: Article
• Acceptance Date: Feb 18, 2017
• Online Publication Date: Mar 17, 2017
• Publication Date: Mar 1, 2017
• Deposit Date: Oct 24, 2023
• Publicly Available Date: Nov 7, 2023
• Journal: PLoS ONE
• Print ISSN: 1932-6203
• Electronic ISSN: 1932-6203
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Issue: 3
• Article Number: e0173228
• DOI: https://doi.org/10.1371/journal.pone.0173228
• Public URL: https://hull-repository.worktribe.com/output/4424646